Development and pathology of Fasciola hepatica in CCL3-deficient mice

Veterinary Parasitology
R C De PaulaM P Guimarães

Abstract

Fasciola hepatica is a parasitic helminth that predominantly infects the liver and bile ducts of cattle and causes great losses of cattle production in the southern and southeastern regions of Brazil. The generation of liver lesions and the consequent inflammatory responses are intimately related to the migration of this parasite. The CC-group of chemokines plays a crucial role in the attraction of several cell types and in the recruitment of additional macrophages to an inflammatory focus in numerous diseases. In order to evaluate the role of CCL3 in the development of F. hepatica, we compared parasitological and pathological parameters in C57Bl/6J mice that were assigned to one of two experimental groups: the first group contained CCL3-producing mice (CCL3(+/+) mice) and the other group contained mice that were genetically deficient in CCL3 production (CCL3(-/-) mice). The mortality rate in the CCL3 non-deficient group was higher than of the deficient animals. In most animals from both experimental groups, the necropsied animals contained hemorrhages in their abdominal cavities. In the genetically modified animals, the lesioned liver areas were less extensive and presented focal and sub-capsular lesions. This work demonstrate...Continue Reading

References

Jun 2, 1979·The Veterinary Record·G A OakleyN H Knapp
Apr 22, 1972·The Veterinary Record·J F ReidF W Jennings
Sep 25, 1999·Infection and Immunity·M T BradyK H Mills
Feb 15, 2000·Parasite Immunology·S M O'NeillJ P Dalton
Jun 11, 2002·The Journal of Parasitology·M Adela ValeroSantiago Mas-Coma
Feb 5, 2008·Parasitology Research·Abdel-Nasser A Hussein, R M A Khalifa

❮ Previous
Next ❯

Citations

Aug 1, 2016·Experimental Parasitology·Mohammad Moazeni, Amin Ahmadi
Jun 1, 2011·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Valeria GayoRoberto Mera y Sierra

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.