Development and Performance of the Pulmonary Embolism Result Forecast Model (PERFORM) for Computed Tomography Clinical Decision Support

JAMA Network Open
Imon BanerjeeMatthew P Lungren

Abstract

Pulmonary embolism (PE) is a life-threatening clinical problem, and computed tomographic imaging is the standard for diagnosis. Clinical decision support rules based on PE risk-scoring models have been developed to compute pretest probability but are underused and tend to underperform in practice, leading to persistent overuse of CT imaging for PE. To develop a machine learning model to generate a patient-specific risk score for PE by analyzing longitudinal clinical data as clinical decision support for patients referred for CT imaging for PE. In this diagnostic study, the proposed workflow for the machine learning model, the Pulmonary Embolism Result Forecast Model (PERFORM), transforms raw electronic medical record (EMR) data into temporal feature vectors and develops a decision analytical model targeted toward adult patients referred for CT imaging for PE. The model was tested on holdout patient EMR data from 2 large, academic medical practices. A total of 3397 annotated CT imaging examinations for PE from 3214 unique patients seen at Stanford University hospitals and clinics were used for training and validation. The models were externally validated on 240 unique patients seen at Duke University Medical Center. The comparis...Continue Reading

References

Feb 1, 1992·American Journal of Public Health·E S FisherD C Hsia
Apr 29, 2005·The New England Journal of Medicine·Arnaud PerrierHenri Bounameaux
Feb 8, 2006·Annals of Internal Medicine·Grégoire Le GalArnaud Perrier
Nov 2, 2007·Journal of Thrombosis and Haemostasis : JTH·F A KlokM V Huisman
May 22, 2009·AJR. American Journal of Roentgenology·Andre B BautistaUNKNOWN American College of Radiology Appropriateness
Jun 1, 2011·Drug Discovery Today·Lixia YaoPankaj Agarwal
May 3, 2012·Nature Reviews. Genetics·Peter B JensenSøren Brunak
May 10, 2012·Journal of Thrombosis and Haemostasis : JTH·A PenalozaF Thys
Oct 1, 2013·Journal of the American Medical Informatics Association : JAMIA·Danning HeSusan Hutfless
Jul 18, 2015·Science·M I Jordan, T M Mitchell
Oct 2, 2015·American Journal of Respiratory and Critical Care Medicine·Renda Soylemez WienerUNKNOWN ATS/ACCP Committee on Low-Dose CT Lung Cancer Screening in Clinical Practice
Nov 30, 2016·AJR. American Journal of Roentgenology·Moritz H AlbrechtU Joseph Schoepf
Dec 22, 2016·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Steven CraneMazin Eragat
Nov 14, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gabriel ChartrandAn Tang
Nov 28, 2017·Journal of Biomedical Informatics·Imon BanerjeeDaniel L Rubin
Jan 9, 2018·JAMA Internal Medicine·Jaron ChongBenoît Gallix
Jan 8, 2019·JAMA : the Journal of the American Medical Association·Ohad OrenJohn P A Ioannidis

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Citations

Feb 28, 2020·Journal of the American Medical Informatics Association : JAMIA·William K DiproseReece Robinson
Mar 25, 2020·Critical Care : the Official Journal of the Critical Care Forum·Guillermo Gutierrez
Jan 8, 2020·Postgraduate Medical Journal·Tanya AggarwalPrashant Nagpal
Oct 13, 2020·Current Cardiovascular Risk Reports·Connor TiceTaisei Kobayashi
Feb 17, 2021·Seminars in Respiratory and Critical Care Medicine·Delphine DouilletAndrea Penaloza
Oct 17, 2020·Current Opinion in Pediatrics·Nicholas L Rider
Mar 21, 2021·NPJ Digital Medicine·David W BatesKyu Rhee
Apr 22, 2021·Bioelectronic Medicine·Nishila MehtaBenjamin Fine
Jun 5, 2021·NPJ Digital Medicine·Amara TariqImon Banerjee
Jun 6, 2021·Mayo Clinic Proceedings·Benjamin A SatterfieldIftikhar J Kullo

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Software Mentioned

ElasticNet
rGeneva
Wells
PERFORM
Pulmonary Embolism Result Forecast Model ( PERFORM )

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