Development and pharmacist-mediated use of tools for monitoring atypical antipsychotic-induced side effects related to blood glucose levels

Pharmacoepidemiology and Drug Safety
Shunsuke IshidaKeisuke Ishizawa

Abstract

Drug side effects often lead to serious outcomes. Administration of second-generation antipsychotics has resulted in diabetic ketoacidosis and diabetic coma leading to death. Therefore, pharmacists are required to collect information on clinical test values, determine the appropriate test timing, and coordinate with doctors for further clinical laboratory orders, all of which are labor-intensive and time-intensive tasks. In this study, we developed a side effect-monitoring tool and aimed to clarify the influence and efficiency of monitoring side effects by using the tool in patients taking atypical antipsychotics in whom it is necessary to check clinical test values such as blood sugar levels. We extracted clinical test values for patients treated with second-generation antipsychotics from electronic medical records. The test values are automatically displayed in the side effect grade classification specified by CTCAE ver. 4.0. A database was constructed using scripts to provide alerts for the timing of clinical testing. The pharmacist used this tool to confirm clinical test values for patients taking medication and requested the physician to inspect orders based on the appropriate test timings. The management tool reduced the ...Continue Reading

References

Jan 30, 2004·Diabetes Care·UNKNOWN American Diabetes AssociationUNKNOWN North American Association for the Study of Obesity
May 30, 2007·Archives of Internal Medicine·Yvonne KwanJana M Bajcar
Jun 3, 2008·The British Journal of Psychiatry : the Journal of Mental Science·M SmithK Ismail
Jul 31, 2008·The Annals of Pharmacotherapy·Ariel HammermanMargalit Goldfracht
Jan 1, 2005·International Journal of Psychiatry in Clinical Practice·A De Nayer On Behalf Of The Consensus Group

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Citations

Aug 5, 2021·Revista brasileira de enfermagem·Fernanda Pâmela MachadoJulia Trevisan Martins

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