Development and prospective validation of a clinical index to predict survival in ambulatory patients referred for cardiac transplant evaluation

Circulation
K D AaronsonD M Mancini

Abstract

Risk stratification of patients with end-stage congestive heart failure is a critical component of the transplant candidate selection process. Accurate identification of individuals most likely to survive without a transplant would facilitate more efficient use of scarce donor organs. Multivariable proportional hazards survival models were developed with the use of data on 80 clinical characteristics from 268 ambulatory patients with advanced heart failure (derivation sample). Invasive and noninvasive models (with and without catheterization-derived data) were constructed. A prognostic score was determined for each patient from each model. Stratum-specific likelihood ratios were used to develop three prognostic-score risk groups. The models were prospectively validated on 199 similar patients (validation sample) by calculation of the area under the receiver operating characteristic curve for 1-year event-free survival, the censored c-index for event-free survival, and comparison of event-free survival curves for prognostic-score risk strata. Outcome events were defined as urgent transplant or death without transplant. The noninvasive model performed well in both samples, and increased performance was not attained by the additio...Continue Reading

References

Feb 1, 1992·American Heart Journal·J ParameshwarP A Poole-Wilson
Jul 26, 1990·The New England Journal of Medicine·B LevineM Packer
May 1, 1990·American Heart Journal·T L KellyR Shabetai
Jun 1, 1989·Journal of the American College of Cardiology·S S GottliebM Packer
Sep 1, 1989·Journal of the American College of Cardiology·A GradmanS Goldstein
Jul 11, 1988·The American Journal of Cardiology·J N Cohn, T S Rector
Sep 26, 1985·The New England Journal of Medicine·J H WassonL Goldman
Apr 1, 1985·The American Journal of Cardiology·J SzlachcicJ Tubau
Sep 1, 1983·Journal of the American College of Cardiology·J R WilsonM E Josephson
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Apr 1, 1984·Statistics in Medicine·F E HarrellR A Rosati
Mar 15, 1984·The American Journal of Cardiology·T MeinertzJ Meyer
Jul 1, 1984·The American Journal of Cardiology·D V UnverferthC V Leier
May 14, 1982·JAMA : the Journal of the American Medical Association·F E HarrellR A Rosati
Nov 8, 1995·JAMA : the Journal of the American Medical Association·J D Sackner-Bernstein, D M Mancini
Nov 1, 1995·Circulation·L W StevensonJ W Creaser
Apr 1, 1993·Medical Decision Making : an International Journal of the Society for Medical Decision Making·J C Peirce, R G Cornell

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Citations

Jun 5, 2008·JAMA : the Journal of the American Medical Association·Larry A AllenG Michael Felker
Mar 5, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·O Kamp
Apr 17, 2009·Herz·Lutz Buellesfeld, Eberhard Grube
Dec 6, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·C ZugckS Störk
Jan 11, 2007·Herzschrittmachertherapie & Elektrophysiologie·H NägeleM A Castel
Aug 12, 2005·Journal of Artificial Organs : the Official Journal of the Japanese Society for Artificial Organs·Tomoe UchiyamaShigeyuki Nishimura
Nov 30, 2006·Heart Failure Reviews·Boaz D RosenRonald D Berger
Mar 3, 2007·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Anne B Curtis
May 15, 2012·Journal of Interventional Cardiac Electrophysiology : an International Journal of Arrhythmias and Pacing·Hyan Suk YangKomandoor Srivathsan
Aug 10, 2002·Current Cardiology Reports·Silke Isabelle TrautmannAngelo Auricchio
Aug 25, 2006·Current Heart Failure Reports·Eugene E Wolfel
Aug 18, 2006·Current Heart Failure Reports·Michael Craig, Naveen L Pereira
May 25, 2007·Current Heart Failure Reports·Jennifer Cowger MatthewsKeith D Aaronson
Jun 30, 2010·Current Heart Failure Reports·Judith Z Goldfinger, Eric D Adler
Nov 9, 2010·Current Heart Failure Reports·Andres Schuster, W H Wilson Tang
Feb 22, 2012·Current Heart Failure Reports·John R Kapoor, Paul A Heidenreich
Oct 1, 2013·Current Heart Failure Reports·A Afşin OktaySanjiv J Shah
Jul 3, 2002·Current Treatment Options in Cardiovascular Medicine·Navinder Sawhney, Mitchell Faddis
Jan 12, 2011·Current Treatment Options in Cardiovascular Medicine·Eldrin F Lewis
Jun 19, 2010·Journal of Cardiovascular Translational Research·Daniel G TangHari R Mallidi
Mar 2, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R S GardnerT A McDonagh
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Eric LimStephen R Large
Jun 1, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Cesar A EgoavilBehzad B Pavri
Apr 20, 2004·International Journal of Cardiology·Giuseppe BorianiAngelo Branzi
Nov 21, 2000·The American Journal of Cardiology·F GaitaL Padeletti
Aug 15, 2003·Current Problems in Cardiology·Audrey H Wu, Robert J Cody
Aug 7, 2002·International Journal of Cardiology·Viviane M ConraadsChristiaan J Vrints
Nov 7, 2002·International Journal of Cardiology·Paul R KalraStefan D Anker
Aug 24, 1999·International Journal of Cardiology·W ShamimA J Coats
Jan 12, 2001·Journal of the American College of Cardiology·L W StevensonA Wichman
Dec 12, 2001·Journal of the American College of Cardiology·L A Saxon, T De Marco
Dec 12, 2001·Journal of the American College of Cardiology·J KoglinW vonScheidt
Jun 27, 2002·Journal of the American College of Cardiology·Angelo AuricchioUNKNOWN Pacing Therapies in Congestive Heart Failure (PATH-CHF) Study Group
Nov 26, 2002·Journal of the American College of Cardiology·Mark T KearneyJames Nolan
Feb 7, 2003·Journal of the American College of Cardiology·Todd M Koelling, Kim A Eagle
Jan 22, 2003·Journal of the American College of Cardiology·Mariell Jessup
May 28, 2003·Journal of the American College of Cardiology·Anju NohriaLynne W Stevenson
Jul 10, 2003·Journal of the American College of Cardiology·Hans RickliHans Peter Brunner-La Rocca

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