Development and Selection of the Human Vγ9Vδ2+ T-Cell Repertoire

Frontiers in Immunology
Carrie R WillcoxBenjamin E Willcox

Abstract

Vγ9Vδ2+ lymphocytes are among the first T-cells to develop in the human fetus and are the predominant peripheral blood γδ T-cell population in most adults. Capable of broad polyclonal responses to pyrophosphate antigens (pAg), they are implicated in immunity to a diverse range of infections. Previously Vγ9Vδ2+ development was thought to involve postnatal selection and amplification of public Vγ9 clonotypes in response to microbial stimuli. However, recent data indicate the Vγ9Vδ2+ T-cell receptor (TCR) repertoire, which is generated early in gestation, is dominated by public Vγ9 clonotypes from birth. These chains bear highly distinct features compared to Vγ9 chains from Vδ1+ T-cells, due either to temporal differences in recombination of each subset and/or potentially prenatal selection of pAg-reactive clonotypes. While these processes result in a semi-invariant repertoire featuring Vγ9 sequences preconfigured for pAg recognition, alterations in TCRδ repertoires between neonate and adult suggest either peripheral selection of clonotypes responsive to microbial antigens or altered postnatal thymic output of Vγ9Vδ2+ T-cells. Interestingly, some individuals demonstrate private Vγ9Vδ2+ expansions with distinct effector phenotypes,...Continue Reading

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Citations

Jan 22, 2019·Nature Immunology·Benjamin E Willcox, Carrie R Willcox
Mar 7, 2019·Frontiers in Immunology·Lars HviidBenjamin E Willcox
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Apr 1, 2020·Cells·Alina Suzann FichtnerImmo Prinz
Aug 16, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maria PapadopoulouDavid Vermijlen
May 8, 2020·JCI Insight·Melinda A BiernackiMarie Bleakley
Oct 22, 2019·European Journal of Immunology·Andrea CossarizzaArturo Zychlinsky
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Oct 16, 2018·Frontiers in Immunology·Martin S DaveyBenjamin E Willcox
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Nov 5, 2020·Immunological Reviews·Maria PapadopoulouDavid Vermijlen
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Aug 1, 2021·American Journal of Reproductive Immunology : AJRI·Qian-Han XuAi-Hua Liao

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