Development and temporal organization of compulsive checking induced by repeated injections of the dopamine agonist quinpirole in an animal model of obsessive-compulsive disorder

Behavioural Brain Research
Anna DvorkinHenry Szechtman

Abstract

Rats treated chronically with the dopamine D2/D3 receptor agonist quinpirole develop locomotor sensitization and exhibit compulsive checking of specific places in an open-field arena, a behavioral profile that may represent an animal model of obsessive-compulsive disorder. However, it is not known how compulsive checking develops across quinpirole injections nor whether checking behavior possesses a particular temporal structure. Male rats received quinpirole (0.5mg/kg, twice weekly x 10) or an equivalent regimen of saline and were placed in a large open field for 55 min where their behavior was digitally tracked for subsequent analysis of checking behavior using existing and newly developed computer software. Results showed that the measures of compulsive checking did not follow a singular profile across injections: some remained constant and others changed monotonically reaching their near-maximum levels after about 5-7 quinpirole injections. Moreover, results showed that checking behavior was organized into bouts of checking, with the number of bouts, as well as the rate of checking within a bout, increasing across injections to reach near maximal levels after about 5-7 administrations of quinpirole. Finally, quinpirole-trea...Continue Reading

References

Sep 1, 1989·Behavioural Brain Research·D Eilam, I Golani
Aug 1, 1994·Pharmacology, Biochemistry, and Behavior·H SzechtmanR M Sullivan
Oct 21, 1998·Journal of Theoretical Biology·B J TolkampI Kyriazakis
Mar 8, 1999·Animal Behaviour·B J Tolkamp, I Kyriazakis
Sep 22, 2001·Neuroscience and Biobehavioral Reviews·D Drai, I Golani
Dec 12, 2001·Journal of Theoretical Biology·M P YeatesI Kyriazakis
Feb 6, 2004·Psychological Review·Henry Szechtman, Erik Woody
Feb 6, 2004·Journal of Neuroscience Methods·Itay HenYoav Benjamini
Oct 21, 2005·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Melissa L PerreaultHenry Szechtman

❮ Previous
Next ❯

Citations

Aug 22, 2009·Behavioural Pharmacology·Gregory T Collins, James H Woods
Jun 2, 2012·Expert Opinion on Drug Discovery·Kurt Leroy Hoffman
Nov 27, 2014·Behavioural Pharmacology·Javier Ballester GonzálezHenry Szechtman
Dec 15, 2010·Journal of Psychopharmacology·Ria de HaasHerman G M Westenberg
Oct 28, 2017·Evolutionary Psychology : an International Journal of Evolutionary Approaches to Psychology and Behavior·Michael J Frederick, Sarah E Cocuzzo
Aug 25, 2010·The European Journal of Neuroscience·Anna DvorkinHenry Szechtman
Dec 13, 2019·Pharmacological Reviews·Henry SzechtmanKurt Leroy Hoffman
Mar 7, 2020·Frontiers in Pharmacology·Angélica Del Pilar EscobarJosé Antonio Fuentealba
Mar 25, 2020·Neurotoxicity Research·Mahdi AbounooriMotahareh Rouhi Ardeshiri
May 23, 2017·The International Journal of Neuropsychopharmacology·Angélica P EscobarMaría E Andrés

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.