Development and testing of a de novo clinical staging system for podoconiosis (endemic non-filarial elephantiasis).

Tropical Medicine & International Health : TM & IH
Fasil TekolaGail Davey

Abstract

To develop and test a robust clinical staging system for podoconiosis, a geochemical disease in individuals exposed to red clay soil. We adapted the Dreyer system for staging filarial lymphoedema and tested it in four re-iterative field tests conducted in an area of high-podoconiosis prevalence in Southern Ethiopia. The system has five stages according to proximal spread of disease and presence of dermal nodules, ridges and bands. We measured the 1-week repeatability and the inter-observer agreement of the final staging system. The five-stage system is readily understood by community workers with little health training. Kappa for 1-week repeatability was 0.88 (95% CI 0.80-0.96), for agreement between health professionals was 0.71 (95% CI 0.60-0.82), while that between health professionals and community podoconiosis agents without formal health training averaged 0.64 (95% CI 0.52-0.78). This simple staging system with good inter-observer agreement and repeatability can assist in the management and further study of podoconiosis.

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Citations

Jul 9, 2009·Annals of Tropical Medicine and Parasitology·G Davey
Jul 21, 2012·PLoS Neglected Tropical Diseases·Yordanos B MollaGail Davey
Oct 17, 2013·PLoS Neglected Tropical Diseases·Kebede DeribeFasil Tekola-Ayele
Dec 18, 2013·PLoS Neglected Tropical Diseases·Yordanos B MollaGail Davey
Sep 14, 2013·International Health·Fasil Tekola AyeleChristel Ahrens
Mar 3, 2015·Medicina clínica·Laura Prieto-PérezMiguel Górgolas Hernández-Mora
Mar 5, 2010·The British Journal of Dermatology·S AddisuM A Titheradge
Nov 18, 2014·Journal of Cutaneous Pathology·Wendemagegn EnbialeAlmut Böer-Auer
Nov 1, 2015·International Journal of Dermatology·Valeska PadoveseAldo Morrone
Aug 31, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Marina Venero GalanternikBrant M Weinstein
May 19, 2018·Nature Communications·Gabriela D García NoresBabak J Mehrara
Jun 28, 2018·BMJ Global Health·Kebede DeribeSamuel Wanji
Jun 15, 2011·PLoS Neglected Tropical Diseases·Getahun AlemuGail Davey
Feb 23, 2019·Lymphatic Research and Biology·Janet Douglass, Louise Kelly-Hope
Oct 3, 2018·Tropical Medicine and Infectious Disease·Damilare O Famakinde, Adedotun A Adenusi
Dec 2, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Bertrand Lontum NdzeshangSamuel Wanji
Nov 22, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Maya SemrauKebede Deribe
Jan 23, 2021·PLoS Neglected Tropical Diseases·Wendemagegn EnbialeHenry J C de Vries
Oct 26, 2020·Transactions of the Royal Society of Tropical Medicine and Hygiene·Diana R AlcantaraMelanie J Newport
Apr 12, 2021·Acta Tropica·Samuel WanjiManuel Ritter
Feb 27, 2020·Dermatology : International Journal for Clinical and Investigative Dermatology·David J ChandlerLucinda C Fuller

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