Development and validation of a computational finite element model of the rabbit upper airway: Simulations of mandibular advancement and tracheal displacement

Journal of Applied Physiology
Jason AmatouryLynne E Bilston

Abstract

The mechanisms leading to upper airway (UA) collapse during sleep are complex and poorly understood. We have previously developed an anaesthetized rabbit model for studying UA physiology. Based on this body of physiological data, we aimed to develop and validate a two-dimensional (2D) computational finite element (FEM) of the passive rabbit UA and peripharyngeal tissues. Model geometry was reconstructed from a mid-sagittal CT image of a representative NZ White rabbit, which included major soft (tongue, soft palate, constrictor muscles), cartilaginous (epiglottis, thyroid cartilage) and bony pharyngeal tissues (mandible, hard palate, hyoid bone). Other UA muscles were modeled as linear elastic connections. Initial boundary and contact definitions were defined from anatomy and material properties derived from the literature. Model parameters were optimized to physiological data sets associated with mandibular advancement (MA) and caudal tracheal displacement (TD), including hyoid displacement, which featured with both applied loads. The model was then validated against independent data sets involving combined MA and TD. Model outputs included UA lumen geometry, peripharyngeal tissue displacement, stress and strain distributions. ...Continue Reading

References

Aug 11, 1992·The American Review of Respiratory Disease·C D BurgerJ W Shepard
Nov 1, 1988·Journal of Applied Physiology·W B Van de Graaff
Jun 1, 1996·American Journal of Respiratory and Critical Care Medicine·W S MezzanotteD P White
Jun 1, 1996·Journal of Applied Physiology·J A RowleyA R Schwartz
Dec 1, 1995·Journal of Applied Physiology·S IsonoT Nishino
Mar 11, 2003·Journal of Applied Physiology·Jason P KirknessDavid R Hillman
Aug 27, 2005·Journal of Applied Physiology·Kristina KairaitisTerence C Amis
Jun 2, 2006·Journal of Biomechanics·Z S LiuC Lu
Jul 14, 2007·The International Journal of Medical Robotics + Computer Assisted Surgery : MRCAS·Stéphanie BuchaillardYohan Payan
Feb 6, 2008·Proceedings of the American Thoracic Society·Andrew S L ChanPeter A Cistulli
Apr 19, 2008·Journal of Applied Physiology·Jason P KirknessSusheel P Patil
May 16, 2008·The Annals of Otology, Rhinology, and Laryngology·Mihai MihaescuManinder Kalra
Sep 15, 2009·Medical Engineering & Physics·Chun XuDavid M Wootton
Oct 10, 2009·The Journal of the Acoustical Society of America·Stéphanie BuchaillardYohan Payan
Jun 17, 2010·IEEE Transactions on Bio-medical Engineering·A D LuceyD R Hillman
Jun 26, 2010·Journal of Applied Physiology·Samuel B SquierAlan R Schwartz
Nov 3, 2010·Journal of Biomechanics·S ChengL E Bilston
Mar 4, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·P D SrodonM J Birch
Mar 26, 2011·Journal of Applied Physiology·Andrew WellmanDavid P White
Mar 2, 2013·Sleep·Elizabeth C BrownLynne E Bilston
Jun 1, 2013·American Journal of Respiratory and Critical Care Medicine·Danny J EckertAndrew Wellman
Jan 31, 2015·Journal of Applied Physiology·Kristina KairaitisTerence C Amis
Jan 1, 2012·International Journal for Numerical Methods in Biomedical Engineering·J-P V Pelteret, B D Reddy

❮ Previous
Next ❯

Citations

Jun 21, 2017·Chest·Jayne C CarberryDanny J Eckert
Sep 13, 2019·Journal of Applied Physiology·Joshua TongJason Amatoury
Mar 9, 2021·Chest·Kristina KairaitisAmy Jordan
Sep 9, 2021·Computer Methods in Biomechanics and Biomedical Engineering·Olusegun J IlegbusiKingman P Strohl

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

© 2022 Meta ULC. All rights reserved