Development and validation of a nomogram for predicting outcome of patients with vulvar cancer

Obstetrics and Gynecology
Roman RouzierBernard-Jean Paniel

Abstract

To construct and validate a nomogram to predict relapse-free survival of patients treated for vulvar cancer. Data from 244 patients treated for vulvar cancer at a single institution (Creteil, France) were used as a training set to develop and calibrate a nomogram for predicting relapse-free survival and local relapse-free survival. We used bootstrap resampling for the internal validation and we tested the nomogram on an independent validation set of patients (Torino, Italy) for the external validation. The nomograms were based on a Cox proportional hazards regression model. Covariates for the relapse-free survival model included age, T stage, number of metastatic nodes, bilateral lymph node involvement, omission of the lymphadenectomy, margin status, lymphovascular space invasion, and depth of invasion. The concordance indices were 0.85 and 0.83 in the training set before and after bootstrapping, respectively, and 0.83 in the validation set. The predictions of our nomogram discriminated better than did the International Federation of Gynecology and Obstetrics stage (0.83 compared with 0.78, P = .01). The calibration of our nomogram was good. In the validation set, 2-year and 5-year relapse-free survival were well predicted with...Continue Reading

References

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Citations

Dec 5, 2014·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Ira WinerRouba Ali-Fehmi
Jan 24, 2013·Cancer Medicine·Koji MatsuoLynda D Roman
Mar 1, 2012·Gynecologic Oncology·Srinivas Kondalsamy-ChennakesavanAndreas Obermair
May 23, 2012·Gynecologic Oncology·Christopher S Awtrey
Aug 9, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·L S NooijM I E van Poelgeest
Aug 23, 2018·American Journal of Clinical Oncology·Eric P XanthopoulosLilie L Lin
Oct 20, 2018·Expert Review of Anticancer Therapy·Tommy Buchanan, David Mutch
Apr 27, 2021·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Jin Liu, Mengqiao Wang
Aug 9, 2021·The Journal of Obstetrics and Gynaecology Research·Hidetaka NomuraHiroyuki Kanao

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