Development and validation of a nomogram to predict survival in incurable cachectic cancer patients on home parenteral nutrition

Annals of Oncology : Official Journal of the European Society for Medical Oncology
F BozzettiL Mariani

Abstract

The use of home parenteral nutrition (HPN) in incurable cancer patients is extremely varied across different countries and institutions. In order to assess the clinical impact implied, we previously conducted a survey of incurable cancer patients receiving HPN, which shows that survival was markedly affected by Karnofsky performance status (KPS), tumor spread, Glasgow prognostic score (GPS) and tumor site. The aim of this study was to develop a nomogram incorporating the above factors for survival prediction. We gathered a series of 579 patients, all receiving HPN, which was randomly split into a training and a testing sample. Using Cox proportional hazard regression modeling, a nomogram was built in the training sample, in order to estimate median survival or survival probability at 3 and 6 months according to individual patient characteristics. The nomogram performance was then verified in the testing sample. In the training sample, median survival was 3.2 (95% CI 3.0-3.7) months. GPS, KPS, tumor site and spread were confirmed to be significant prognostic factors. A significant interaction was also shown between the site and spread while weight loss (WL), adjusted for body mass index, failed to provide any substantial prognos...Continue Reading

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Citations

May 2, 2017·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Emmanuelle KempfLucas Morin
Aug 11, 2018·The Cochrane Database of Systematic Reviews·Anne Marie SowerbuttsSorrel Burden
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May 18, 2020·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Federico Bozzetti
Sep 19, 2017·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Lidia Santarpia, Federico Bozzetti
Jan 12, 2021·The Oncologist·Federico Bozzetti
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