Development and validation of a noncontact spectroscopic device for hemoglobin estimation at point-of-care

Journal of Biomedical Optics
Probir Kumar SarkarSamir Kumar Pal

Abstract

Anemia severely and adversely affects human health and socioeconomic development. Measuring hemoglobin with the minimal involvement of human and financial resources has always been challenging. We describe a translational spectroscopic technique for noncontact hemoglobin measurement at low-resource point-of-care settings in human subjects, independent of their skin color, age, and sex, by measuring the optical spectrum of the blood flowing in the vascular bed of the bulbar conjunctiva. We developed software on the LabVIEW platform for automatic data acquisition and interpretation by nonexperts. The device is calibrated by comparing the differential absorbance of light of wavelength 576 and 600 nm with the clinical hemoglobin level of the subject. Our proposed method is consistent with the results obtained using the current gold standard, the automated hematology analyzer. The proposed noncontact optical device for hemoglobin estimation is highly efficient, inexpensive, feasible, and extremely useful in low-resource point-of-care settings. The device output correlates with the different degrees of anemia with absolute and trending accuracy similar to those of widely used invasive methods. Moreover, the device can instantaneously...Continue Reading

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Citations

Aug 22, 2018·Physiological Measurement·A T SufianJ W Spencer
Jan 18, 2019·Annals of the New York Academy of Sciences·Crystal D KarakochukUNKNOWN HEmoglobin MEasurement (HEME) Working Group
May 28, 2020·BMC Health Services Research·Sutapa Bandyopadhyay NeogiRenu Saxena

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