Development and validation of a photometric titration method for the quantitation of sodium chondroitin sulfate (bovine) in Cosequin DS chewable tablet

Journal of Pharmaceutical and Biomedical Analysis
Zhongming LiangTodd Henderson

Abstract

A photometric titration method was developed and validated to quantitate sodium chondroitin sulfate in raw materials and Cosequin DS chewable tablet(1). About 0.1% (w/v) cetylpyridinium chloride was used to titrate sodium chondroitin sulfate with photometric indication at wavelength 420 nm. The standard curves for sodium chondroitin sulfate showed linearity (r> or = 0.99) over the selected concentration range from 0.6 to 1.4 mg/ml. The chewable tablet was ground to fine powder and extracted with water and the resulting solutions filtered through a 0.45 microm membrane filter. Recovery between 97 and 103%,. The intra- and inter- day precision as indicated by the relative standard deviation (R.S.D.) were not greater than 0.33 and 0.78%, respectively. The method was found to be specific and with excellent linearity, accuracy and precision and is well suited for the quantitation of sodium chondroitin sulfate in raw material and Cosequin DS chewable tablet.

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Citations

Apr 2, 2003·Journal of Pharmaceutical and Biomedical Analysis·Don Woong ChoiSeung Yeup Chang
Apr 14, 2005·Journal of the American Veterinary Medical Association·Kirsten M NeilMichael W Orth
Oct 30, 2014·Artificial Cells, Nanomedicine, and Biotechnology·Gözde Baydemir
Nov 22, 2005·The Veterinary Clinics of North America. Equine Practice·Troy N Trumble
Sep 14, 2010·Journal of Colloid and Interface Science·Marcos R GuilhermeElias B Tambourgi
Dec 7, 2007·Analytical Biochemistry·Christina J MalavakiNikos K Karamanos

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