PMID: 11910597Mar 26, 2002Paper

Development and validation of a physical examination scale to assess vaginal atrophy and inflammation

Climacteric : the Journal of the International Menopause Society
G A GreendaleP A Ganz

Abstract

The assessment of vaginal atrophy is central to menopause-related research and clinical practice. However, methods of grading vaginal atrophy have not been subjected to reliability and validity assessments. To assess the validity and reproducibility of selected vaginal examination findings proposed to represent vaginal atrophy and inflammation. Cross-sectional study. A convenience sample of 40 postmenopausal volunteers with past history of breast cancer. Participants completed questionnaires to assess vaginal symptoms. Pelvic examinations were carried out using specified criteria to assess the vaginal appearance. Vaginal cytological smears and pH measurements were performed using standardized techniques. A four-item physical examination atrophy scale had an alpha reliability of 0.48 and was statistically significantly correlated with pH (r = 0.55) and parabasal cells (r = 0.50). A three-item physical examination inflammation scale had an alpha reliability of 0.45. It was not significantly associated with vaginal smear-measured inflammation. Masked inter-rater agreement for the examination was 90%. Self-reported symptoms of itching/irritation or dryness were poorly related to findings on physical examination. These results offer...Continue Reading

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Citations

Mar 21, 2001·Menopause : the Journal of the North American Menopause Society·G A GreendaleP A Ganz
Apr 18, 2007·Menopause : the Journal of the North American Menopause Society·UNKNOWN North American Menopause Society
Apr 23, 2008·Menopause : the Journal of the North American Menopause Society·Rachel HessRoberta B Ness
Jan 10, 2009·Menopause : the Journal of the North American Menopause Society·James A Simon
Mar 7, 2014·Menopause : the Journal of the North American Menopause Society·Caroline M Mitchell, Susan D Reed
Mar 31, 2015·Journal of Personalized Medicine·Joanne LesterMaryam Lustberg
Jan 16, 2014·Climacteric : the Journal of the International Menopause Society·R E Nappi, S Palacios
Oct 5, 2010·Climacteric : the Journal of the International Menopause Society·D W SturdeeUNKNOWN International Menopause Society Writing Group
Jan 1, 2010·Mayo Clinic Proceedings·Maire B Mac BrideLynne T Shuster
Sep 28, 2010·Dermatologic Therapy·Catherine S Stika
Jul 23, 2014·International Urogynecology Journal·M A WeberJ P W R Roovers
May 25, 2016·Menopause : the Journal of the North American Menopause Society·Maaike A WeberJan-Paul Roovers
Sep 19, 2015·PloS One·M A WeberJ P Roovers
Dec 6, 2017·Menopause : the Journal of the North American Menopause Society·Caroline M MitchellDavid N Fredricks
Aug 8, 2018·Menopause : the Journal of the North American Menopause Society·Caroline M MitchellKatherine A Guthrie
Mar 22, 2019·Expert Opinion on Pharmacotherapy·Gilbert G G DondersSvitrigaile Grinceviciene
Jan 3, 2019·Menopause : the Journal of the North American Menopause Society·Joanie MercierChantale Dumoulin
Apr 19, 2017·Menopause : the Journal of the North American Menopause Society·James A SimonSebastian Mirkin
Feb 28, 2020·Climacteric : the Journal of the International Menopause Society·J MercierC Dumoulin
Jun 24, 2017·Menopause : the Journal of the North American Menopause Society·Caroline M MitchellDavid N Fredricks
Aug 8, 2018·JAMA Internal Medicine·Caroline M MitchellKatherine A Guthrie
Aug 4, 2020·Menopause : the Journal of the North American Menopause Society·Caroline M Mitchell
Jul 1, 2020·Menopause : the Journal of the North American Menopause Society·Vanessa A Lukas, James A Simon
Jul 1, 2020·Menopause : the Journal of the North American Menopause Society·Caroline M MitchellKatherine A Guthrie
Mar 7, 2021·Post Reproductive Health·Paula Briggs, Dharani K Hapangama
Aug 28, 2021·World Journal of Clinical Cases·Daniela BarrosPatricia Lordelo

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