Development and validation of a prognostic model for survival in patients treated with venoarterial extracorporeal membrane oxygenation: the PREDICT VA-ECMO score

European Heart Journal. Acute Cardiovascular Care
Tobias WengenmayerDawid L Staudacher

Abstract

Several scoring systems have been introduced for prognostication after initiating venoarterial extracorporeal membrane oxygenation (VA-ECMO) therapy. However, static scores offer limited guidance once VA-ECMO is implanted, although continued allocation of healthcare resources is critical. Patients requiring continued VA-ECMO support are extremely unstable, with minimal heart function and multi-organ failure in most cases. The aim of the present study was to develop and validate a dynamic prognostic model for patients treated with VA-ECMO. A derivation cohort included 205 all-comers undergoing VA-ECMO implantation at a tertiary referral hospital (51% received VA-ECMO during resuscitation and 43% had severe shock). Two prediction models based on point-of-care biomarkers were developed using penalised logistic regression in an elastic net approach. A validation cohort was recruited from an independent tertiary referral hospital. Comparators for the prediction of hospital survival were the SAVE score (area under the receiver operation characteristic curve (AUC) of 0.686), the SAPS score (AUC 0.679), the APACHE score (AUC 0.662) and the SOFA score (AUC 0.732) in 6-hour survivors. The 6-hour PREDICT VA-ECMO score (based on lactate, p...Continue Reading

References

Dec 17, 2010·Current Heart Failure Reports·Daniel Goldstein, Siyamek Neragi-Miandoab
Nov 15, 2011·Critical Care Medicine·Sarah M PermanRaina M Merchant
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Jun 24, 2017·Critical Care : the Official Journal of the Critical Care Forum·Tobias WengenmayerDawid L Staudacher

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Citations

Apr 28, 2020·Journal of Cardiac Surgery·Brian AyersIgor Gosev
Aug 11, 2020·Journal of the American Heart Association·Marinos KosmopoulosDavid G Benditt
May 28, 2020·European Heart Journal. Acute Cardiovascular Care·Marie RenaudierNicolas Mongardon
Jul 6, 2019·Frontiers in Cardiovascular Medicine·Achim LotherDaniel Duerschmied
Apr 1, 2020·Biometrical Journal. Biometrische Zeitschrift·Marco ChiabudiniErika Graf
Apr 18, 2020·Critical Care Medicine·J Kyle BohmanBhavesh M Patel
Feb 21, 2021·European Heart Journal. Acute Cardiovascular Care·Marie RenaudierNicolas Mongardon
Mar 26, 2021·Seminars in Dialysis·David T Selewski, Keith M Wille
Mar 30, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Jonathan RilingerTobias Wengenmayer
May 5, 2021·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Xavier BemtgenDawid L Staudacher
Aug 1, 2021·Journal of Cardiothoracic and Vascular Anesthesia·Michael E PlazakMichael A Mazzeffi
Aug 7, 2021·Membranes·Neel Shah, Ahmed S Said
Feb 4, 2022·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Dustin HillersonVedant A Gupta

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