Development and validation of a risk factor-based system to predict short-term survival in adult hospitalized patients with COVID-19: a multicenter, retrospective, cohort study

Critical Care : the Official Journal of the Critical Care Forum
Shuai ZhangYang Jin

Abstract

Coronavirus disease 2019 (COVID-19) has become a public health emergency of global concern. We aimed to explore the risk factors of 14-day and 28-day mortality and develop a model for predicting 14-day and 28-day survival probability among adult hospitalized patients with COVID-19. In this multicenter, retrospective, cohort study, we examined 828 hospitalized patients with confirmed COVID-19 hospitalized in Wuhan Union Hospital and Central Hospital of Wuhan between January 12 and February 9, 2020. Among the 828 patients, 516 and 186 consecutive patients admitted in Wuhan Union Hospital were enrolled in the training cohort and the validation cohort, respectively. A total of 126 patients hospitalized in Central Hospital of Wuhan were enrolled in a second external validation cohort. Demographic, clinical, radiographic, and laboratory measures; treatment; proximate causes of death; and 14-day and 28-day mortality are described. Patients' data were collected by reviewing the medical records, and their 14-day and 28-day outcomes were followed up. Of the 828 patients, 146 deaths were recorded until May 18, 2020. In the training set, multivariate Cox regression indicated that older age, lactate dehydrogenase level over 360 U/L, neutrop...Continue Reading

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Citations

Aug 30, 2020·Critical Care : the Official Journal of the Critical Care Forum·Shiping ZhuWanru Cai
Dec 29, 2020·PloS One·Ali A El-SolhKari A Mergenhagen
Jan 17, 2021·The American Journal of Emergency Medicine·Daniel Martin SimadibrataNaufal Arkan Abiyyu Ibrahim
Nov 19, 2020·Open Forum Infectious Diseases·David N FismanR Tuite
Feb 23, 2021·Reviews in Endocrine & Metabolic Disorders·Giovanni CoronaMario Maggi
Dec 8, 2020·Chest·Beatriz DietlUNKNOWN COMUTE Study Group
Mar 30, 2021·Computational and Structural Biotechnology Journal·Bo ChenHuaqin Pan
Jun 12, 2021·Frontiers in Medicine·Yayun LiGuangtong Deng
Sep 11, 2020·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Shuai ZhangYang Jin
Jul 27, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Milena S MarcolinoCarisi A Polanczyk
Jul 7, 2021·International Journal of Clinical Practice·Juan R Ulloque-BadaraccoAdrian V Hernandez
Jul 26, 2021·BMC Medical Informatics and Decision Making·William GalanterHoushang Darabi

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