Development and validation of a risk prediction model in patients with adult congenital heart disease

International Journal of Cardiology
Vivan J M BaggenJolien W Roos-Hesselink

Abstract

To develop and validate a clinically useful risk prediction tool for patients with adult congenital heart disease (ACHD). A risk model was developed in a prospective cohort of 602 patients with moderate/complex ACHD who routinely visited the outpatient clinic of a tertiary care centre in the Netherlands (2011-2013). This model was externally validated in a retrospective cohort of 402 ACHD patients (Czech Republic, 2004-2013). The primary endpoint was the 4-year risk of death, heart failure, or arrhythmia, which occurred in 135 of 602 patients (22%). Model development was performed using multivariable logistic regression. Model performance was assessed with C-statistics and calibration plots. Of the 14 variables that were selected by an expert panel, the final prediction model included age (OR 1.02, 95%CI 1.00-1.03, p = 0.031), congenital diagnosis (OR 1.52, 95%CI 1.03-2.23, p = 0.034), NYHA class (OR 1.74, 95%CI 1.07-2.84, p = 0.026), cardiac medication (OR 2.27, 95%CI 1.56-3.31, p < 0.001), re-intervention (OR 1.41, 95%CI 0.99-2.01, p = 0.060), BMI (OR 1.03, 95%CI 0.99-1.07, p = 0.123), and NT-proBNP (OR 1.63, 95%CI 1.45-1.84, p < 0.001). Calibration-in-the-large was suboptimal, reflected by a lower observed event rate in the ...Continue Reading

Citations

Apr 30, 2020·Seminars in Cardiothoracic and Vascular Anesthesia·Nicholas M Houska, Lawrence I Schwartz
Sep 12, 2019·F1000Research·Jelle P G van der VenWillem A Helbing
Dec 15, 2020·European Heart Journal. Quality of Care & Clinical Outcomes·Laurie W GeenenJolien W Roos-Hesselink
Oct 6, 2019·The Journal of Thoracic and Cardiovascular Surgery·Emma Lei LeiJane Heggie
May 1, 2021·Journal of the American College of Cardiology·Gerhard-Paul DillerAriane Marelli
Aug 29, 2020·Journal of Biomedical Informatics·Renji P CherianSunder Venkitachalam

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