Development and validation of a risk score for hospitalization for heart failure in patients with Type 2 diabetes mellitus.

Cardiovascular Diabetology
Xilin YangJuliana C N Chan

Abstract

There are no risk scores available for predicting heart failure in Type 2 diabetes mellitus (T2DM). Based on the Hong Kong Diabetes Registry, this study aimed to develop and validate a risk score for predicting heart failure that needs hospitalisation in T2DM. 7067 Hong Kong Chinese diabetes patients without history of heart failure, and without history and clinical evidence of coronary heart disease at baseline were analyzed. The subjects have been followed up for a median period of 5.5 years. Data were randomly and evenly assigned to a training dataset and a test dataset. Sex-stratified Cox proportional hazard regression was used to obtain predictors of HF-related hospitalization in the training dataset. Calibration was assessed using Hosmer-Lemeshow test and discrimination was examined using the area under receiver's operating characteristic curve (aROC) in the test dataset. During the follow-up, 274 patients developed heart failure event/s that needed hospitalisation. Age, body mass index (BMI), spot urinary albumin to creatinine ratio (ACR), HbA1c, blood haemoglobin (Hb) at baseline and coronary heart disease during follow-up were predictors of HF-related hospitalization in the training dataset. HF-related hospitalization ...Continue Reading

References

Jan 1, 1991·American Heart Journal·K M AndersonW B Kannel
Dec 1, 1996·Endocrinology and Metabolism Clinics of North America·G A Bray
Oct 14, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·F MetivierG M London
Jul 13, 2001·JAMA : the Journal of the American Medical Association·R B D'AgostinoUNKNOWN CHD Risk Prediction Group
Aug 31, 2001·Journal of the American College of Cardiology·T B HorwichJ H Tillisch
Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Jul 10, 2002·Stroke; a Journal of Cerebral Circulation·Viti KothariRudy R Holman
Mar 1, 2003·Diabetes Care·Laurent VaurUNKNOWN DIABHYCAR Study Group (type 2 DIABetes, Hypertension, CARdiovascular Events and Ramipril) study
Apr 22, 2004·Journal of Cardiac Failure·Melinda L HockensmithRobert W Schrier
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Gregory A NicholsJonathan B Brown
Oct 13, 2005·Statistics in Medicine·Lloyd E Chambless, Guoqing Diao
Nov 29, 2005·The American Journal of Cardiology·Albert A CarrShahnaz Shahinfar
Dec 6, 2005·Journal of the American College of Cardiology·Erik IngelssonLars Lind
Mar 7, 2006·Journal of the American College of Cardiology·Nithima ChaowalitPatricia A Pellikka
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Mar 1, 2008·The American Journal of Cardiology·Xilin YangPeter C Y Tong
Mar 12, 2008·Archives of Internal Medicine·UNKNOWN Hong Kong Diabetes RegistryJuliana C N Chan

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Citations

Jun 10, 2011·Current Cardiovascular Risk Reports·Juliana C N ChanXilin Yang
Oct 28, 2008·Diabetes Research and Clinical Practice·Andrea Luk, Juliana C N Chan
Apr 14, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Vivian Yawei GuoBenny Chung-Ying Zee
Jun 1, 2014·Journal of Diabetes and Its Complications·Daniela Martins-MendesRaquel Soares
Feb 18, 2015·Diabetes Research and Clinical Practice·Ying WangThomas H Marwick
Jan 1, 2015·Diabetes Research and Clinical Practice·Juliana C N ChanUNKNOWN JADE Collaborative Study Group
Oct 16, 2015·Journal of Diabetes Science and Technology·Simon Lebech CichoszOle Hejlesen
Apr 26, 2012·World Journal of Diabetes·Xi-Lin Yang, Juliana Cn Chan
Aug 23, 2018·Journal of Comparative Effectiveness Research·Bin WuHaixiang Wu
Sep 5, 2019·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Wen SuJianwei Xuan
Mar 1, 2015·Expert Review of Endocrinology & Metabolism·Jayne Smith-PalmerJay P Bae
Jan 21, 2020·Diabetes/metabolism Research and Reviews·Lee-Ling LimAlice P S Kong
Jun 15, 2018·Clinical Medicine Insights. Cardiology·Merlin C Thomas
May 30, 2021·European Journal of Heart Failure·Gian Paolo Fadini, Angelo Avogaro
Jun 14, 2021·Journal of Biomedical Informatics·Lucía A Carrasco-RibellesJuan M García-Gómez

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Software Mentioned

SAS
Statistical Analysis System
DIABCARE

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