Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score

Archives of Internal Medicine
Graziano OnderTischa J M van der Cammen

Abstract

The aim of the present study was to develop and validate a method of identifying elderly patients who are at increased risk for an adverse drug reaction (ADR). Data from the Gruppo Italiano di Farmacoepidemiologia nell'Anziano (Italian Group of Pharmacoepidemiology in the Elderly) were used to develop an ADR risk score. Variables associated with ADRs were identified by a stepwise logistic regression analysis and used to compute the ADR risk score. The ADR risk score was then validated in a sample of older adults who were admitted to 4 university hospitals in Europe (validation study). Of 5936 patients (mean [SD] age, 78.0 [7.2] years) in the Gruppo Italiano di Farmacoepidemiologia nell'Anziano sample, 383 (6.5%) experienced an ADR. The number of drugs and a history of an ADR were the strongest predictors of ADRs, followed by heart failure, liver disease, presence of 4 or more conditions, and renal failure. These variables were used to compute the ADR risk score. The area under the receiver operator characteristic curve, which assesses the ability of the risk score to predict ADRs, was 0.71 (95% confidence interval, 0.68-0.73). Overall, 483 patients entered the validation study (mean [SD] age, 80.3 [7.6] years), and 56 (11.6%) e...Continue Reading

Citations

Nov 1, 2010·Therapeutic Delivery·Leslie Garson, Bill Bruns
Aug 6, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Graziano OnderUNKNOWN Geriatrics Working Group of the Italian Medicines Agency
Jan 22, 2014·European Journal of Internal Medicine·Nicola ScichiloneVincenzo Bellia
Feb 25, 2014·Journal of the American Medical Directors Association·Andrea D FoebelGraziano Onder
Nov 10, 2013·European Journal of Internal Medicine·Yen-Chia ChenChen-Chang Yang
Sep 24, 2013·European Journal of Internal Medicine·Davide L VetranoGraziano Onder
Jun 1, 2014·Journal of the American Medical Directors Association·Graziano OnderRoberto Bernabei
Sep 7, 2014·Drugs & Aging·Papapit TuchindaKanokvalai Kulthanan
Mar 19, 2014·Age and Ageing·Matteo TosatoUNKNOWN Investigators of the CRIME Study
Nov 5, 2014·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Hisham M R B OmerJamie J Coleman
Nov 19, 2014·Journal of the American Medical Directors Association·Christophe HeinFati Nourhashémi
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fabio SalviAntonio Cherubini
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Andrea CorsonelloFabrizia Lattanzio
Jan 1, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Fabrizia LattanzioAndrea Corsonello
Feb 16, 2011·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michael A SteinmanKenneth E Schmader
Nov 1, 2011·Critical Care Medicine·Sandra L Kane-GillJeffrey M Rothschild
Jan 6, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Graziano OnderUNKNOWN SHELTER Project
Jul 7, 2012·Zeitschrift für Gerontologie und Geriatrie·P Dovjak
May 31, 2011·Age and Ageing·Denis O'Mahony, Marie N O'Connor
Mar 30, 2013·Age and Ageing·Graziano OnderChakravarthi Rajkumar
Oct 8, 2013·The Journal of Nutrition, Health & Aging·B TangiisuranG Davies
Jul 19, 2012·Wiener medizinische Wochenschrift·Birgit BöhmdorferEkkehard Schweitzer
Mar 18, 2011·Journal of the American Geriatrics Society·Michael A SteinmanPeter J Kaboli
Mar 6, 2012·The American Journal of Medicine·Ian A ScottCharles A Mitchell
Dec 23, 2014·European Journal of Clinical Pharmacology·Gudrun HefnerChristoph Hiemke
Mar 18, 2016·Expert Review of Clinical Pharmacology·Fabio AgustaNicola Scichilone
Oct 16, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Lukshe KanagaratnamRachid Mahmoudi
Dec 10, 2014·International Journal of Clinical Pharmacy·Narjes Saheb Sharif-AskariAli Al Sayed Hussain
Nov 11, 2016·Annals of the American Thoracic Society·Gwen S SklootUNKNOWN ATS ad hoc Committee on Asthma in the Elderly
Nov 10, 2017·Journal of the American Medical Informatics Association : JAMIA·Jan HorskyHarley Z Ramelson
Feb 3, 2016·Therapeutic Advances in Drug Safety·Amanda Hanora Lavan, Paul Gallagher
Aug 1, 2012·Therapeutic Advances in Drug Safety·Sujo AnathhanamJeremy Robson
Jan 11, 2018·Therapeutic Advances in Drug Safety·Amanda LavanDenis O'Mahony
Feb 14, 2016·European Journal of Clinical Pharmacology·A C B van Orten-LuitenR F Witkamp
Aug 24, 2018·PloS One·Jacqueline M BosCornelis Kramers

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.