Development and validation of a scoring index to predict the presence of lesions in capsule endoscopy in patients with suspected Crohn's disease of the small bowel: a Spanish multicenter study

European Journal of Gastroenterology & Hepatology
Juan Egea-ValenzuelaFernando Carballo Álvarez

Abstract

Capsule endoscopy (CE) is the first-line investigation in cases of suspected Crohn's disease (CD) of the small bowel, but the factors associated with a higher diagnostic yield remain unclear. Our aim is to develop and validate a scoring index to assess the risk of the patients in this setting on the basis of biomarkers. Data on fecal calprotectin, C-reactive protein, and other biomarkers from a population of 124 patients with suspected CD of the small bowel studied by CE and included in a PhD study were used to build a scoring index. This was first used on this population (internal validation process) and after that on a different set of patients from a multicenter study (external validation process). An index was designed in which every biomarker is assigned a score. Three risk groups have been established (low, intermediate, and high). In the internal validation analysis (124 individuals), patients had a 10, 46.5, and 81% probability of showing inflammatory lesions in CE in the low-risk, intermediate-risk, and high-risk groups, respectively. In the external validation analysis, including 410 patients from 12 Spanish hospitals, this probability was 15.8, 49.7, and 80.6% for the low-risk, intermediate-risk, and high-risk groups...Continue Reading

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Citations

Mar 8, 2019·Current Opinion in Gastroenterology·Stefania Chetcuti ZammitReena Sidhu
Aug 19, 2020·Digestive Diseases and Sciences·Thomas ChateauLaurent Peyrin-Biroulet
May 30, 2019·Revista Española De Enfermedades Digestivas : Organo Oficial De La Sociedad Española De Patología Digestiva·Juan Egea ValenzuelaFernando Alberca de Las Parras
Aug 6, 2019·Scandinavian Journal of Gastroenterology·Rui de Sousa MagalhãesJosé Cotter

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