Development and Validation of an Algorithm for Identifying Patients with Hemophilia A in an Administrative Claims Database

Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Jennifer LyonsStephan Lanes

Abstract

The accuracy with which hemophilia A can be identified in claims databases is unknown. Develop and validate an algorithm using predictive modeling supported by machine learning to identify patients with hemophilia A in an administrative claims database. We first created a screening algorithm using medical and pharmacy claims to identify potential hemophilia A patients in the US HealthCore Integrated Research Database between January 1, 2006 and April 30, 2015. Medical records for a random sample of patients were reviewed to confirm case status. In this validation sample, we used lasso logistic regression with cross-validation to select covariates in claims data and develop a predictive model to estimate the probability of being a confirmed hemophilia A case. The screening algorithm identified 2,252 patients and we reviewed medical records for 400 of these patients. The screening algorithm had a positive predictive value (PPV) of 65%. The predictive model identified 18 predictors of being a hemophilia A case or noncase. The strongest predictors of case status included male sex, factor VIII therapy, office visits for hemophilia A, and hospitalizations for hemophilia A. The strongest predictors of noncase status included hospitali...Continue Reading

Citations

Apr 9, 2020·Haemophilia : the Official Journal of the World Federation of Hemophilia·Ryan FarejRobert F Sidonio
Jun 11, 2021·Thrombosis Research·Arafat Ul AlamHaowei Linda Sun
Jul 10, 2021·Journal of Comparative Effectiveness Research·Eleanor O CaplanBrandon T Suehs

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