Development and validation of automated SPE-HPLC-MS/MS methods for the quantification of asenapine, a new antipsychotic agent, and its two major metabolites in human urine.

Biomedical Chromatography : BMC
Theo de BoerHolger Lass

Abstract

To support the evaluation of the pharmacokinetic parameters of asenapine (ASE) in urine, we developed and validated online solid-phase extraction high-performance liquid chromatography methods with tandem mass spectrometry detection (SPE-LC-MS/MS) for the quantification of ASE and two of its major metabolites, N-desmethylasenapine (DMA) and asenapine-N⁺-glucuronide (ASG). The linearity in human urine was found acceptable for quantification in a concentration range of 0.500-100 ng/mL for ASE and DMA and 10.0-3000 ng/mL for ASG, respectively.

References

Mar 1, 2008·Journal of Psychopharmacology·M ShahidE H F Wong
Dec 24, 2010·Drug Metabolism and Disposition : the Biological Fate of Chemicals·S F M van de Wetering-KrebbersM L P S van Iersel

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Citations

Jan 14, 2016·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Pavel SistikPetr Bednar
Nov 19, 2014·Journal of Chromatographic Science·Xingjiang HuJianzhong Shen-Tu
Jan 2, 2015·European Journal of Clinical Pharmacology·Peter DogteromPierre A M Peeters
Nov 15, 2012·Therapeutic Drug Monitoring·Lisbeth PatteetHugo Neels

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