Development and validation of immune dysfunction score to predict 28-day mortality of sepsis patients

PloS One
Wen-Feng FangMeng-Chih Lin

Abstract

Sepsis-induced immune dysfunction ranging from cytokines storm to immunoparalysis impacts outcomes. Monitoring immune dysfunction enables better risk stratification and mortality prediction and is mandatory before widely application of immunoadjuvant therapies. We aimed to develop and validate a scoring system according to patients' immune dysfunction status for 28-day mortality prediction. A prospective observational study from a cohort of adult sepsis patients admitted to ICU between August 2013 and June 2016 at Kaohsiung Chang Gung Memorial Hospital in Taiwan. We evaluated immune dysfunction status through measurement of baseline plasma Cytokine levels, Monocyte human leukocyte-DR expression by flow cytometry, and stimulated immune response using post LPS stimulated cytokine elevation ratio. An immune dysfunction score was created for 28-day mortality prediction and was validated. A total of 151 patients were enrolled. Data of the first consecutive 106 septic patients comprised the training cohort, and of other 45 patients comprised the validation cohort. Among the 106 patients, 21 died and 85 were still alive on day 28 after ICU admission. (mortality rate, 19.8%). Independent predictive factors revealed via multivariate log...Continue Reading

References

Oct 1, 1996·Intensive Care Medicine·H D VolkW J Kox
Apr 29, 2000·Intensive Care Medicine·W J KoxH D Volk
Jan 31, 2002·Immunologic Research·R C ReddyT J Standiford
Mar 27, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jean-Louis VincentMarc-Jacques Dubois
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Oct 22, 2005·American Journal of Respiratory and Critical Care Medicine·Jean-Louis Vincent, Edward Abraham
Dec 3, 2009·JAMA : the Journal of the American Medical Association·Jean-Louis VincentUNKNOWN EPIC II Group of Investigators
Dec 15, 2010·Intensive Care Medicine·Mark W HallJoseph A Carcillo
Jun 15, 2011·BMJ : British Medical Journal·Jason PhuaUNKNOWN MOSAICS Study Group
Sep 29, 2011·Anesthesiology·Lee P SkrupkyRichard S Hotchkiss
Nov 15, 2011·Journal of Critical Care·Eduardo TamayoFrancisco Javier Álvarez
Dec 22, 2011·JAMA : the Journal of the American Medical Association·Jonathan S BoomerRichard S Hotchkiss
Jan 29, 2013·Critical Care Medicine·R Phillip DellingerUNKNOWN Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup
Feb 23, 2013·The Lancet Infectious Diseases·Richard S HotchkissDidier Payen
Apr 18, 2013·American Journal of Respiratory and Critical Care Medicine·Jenneke LeentjensPeter Pickkers
Nov 16, 2013·Nature Reviews. Immunology·Richard S HotchkissDidier Payen
Jan 8, 2014·Critical Care : the Official Journal of the Critical Care Forum·Guillaume Monneret, Fabienne Venet
May 20, 2014·JAMA : the Journal of the American Medical Association·Vincent LiuTheodore J Iwashyna
Mar 15, 2015·Science·Richard S Hotchkiss, Edward R Sherwood
Jul 2, 2015·Stroke; a Journal of Cerebral Circulation·Kyle B WalshOpeolu Adeoye
Sep 29, 2015·American Journal of Respiratory and Critical Care Medicine·Carolin FleischmannUNKNOWN International Forum of Acute Care Trialists
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Christopher W SeymourDerek C Angus
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Manu Shankar-HariUNKNOWN Sepsis Definitions Task Force
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Feb 27, 2016·The Lancet. Respiratory Medicine·Emma E DavenportJulian C Knight
Mar 16, 2016·JAMA : the Journal of the American Medical Association·Lonneke A van VughtUNKNOWN MARS Consortium
May 12, 2016·American Journal of Respiratory and Critical Care Medicine·Carolyn S Calfee
May 21, 2016·Frontiers in Immunology·Fabiane SônegoFernando Queiróz Cunha

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Citations

Oct 4, 2020·BMC Medical Informatics and Decision Making·Guilan KongYonghua Hu
Jan 26, 2021·International Journal of Clinical Practice·Concepción Beneyto-RipollMaría de Los Ángeles Carbonell-Torregrosa
Jul 28, 2021·American Journal of Infection Control·Deyuan ZhiMeili Duan

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Methods Mentioned

BETA
flow
flow cytometry

Software Mentioned

MedCalc
MILLIPLEX® Analyst

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