Development and Validation of Novel Dietary and Lifestyle Inflammation Scores

The Journal of Nutrition
Doratha A ByrdRoberd M Bostick

Abstract

Chronically higher inflammation, which may partly result from diet and lifestyle, is implicated in risk for multiple chronic diseases. The dietary inflammatory index (DII) and empirical dietary inflammatory pattern (EDIP), developed to characterize dietary contributions to systemic inflammation, have several limitations. There are no scores to characterize contributions of lifestyle to inflammation. To reflect dietary/lifestyle contributions to inflammation, we developed novel, inflammation biomarker panel-weighted, dietary (DIS) and lifestyle (LIS) inflammation scores in a subset (n = 639) of the Reasons for Geographic and Racial Differences in Stroke Study (REGARDS) cohort. We selected a priori 19 food groups and 4 lifestyle characteristics to comprise the DIS and LIS, respectively. We calculated the components' weights based on their strengths of association with an inflammation biomarker score [comprising high-sensitivity C-reactive protein (hsCRP), IL-6, IL-8, and IL-10] using multivariable linear regression. The sums of the weighted components constitute the scores, such that higher scores reflect, on balance, more proinflammatory exposures. We calculated the DIS, LIS, DII, and EDIP with cross-sectional data from the rema...Continue Reading

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Citations

Sep 2, 2020·Journal of the American College of Nutrition·Kristin M NiemanChristopher J Cifelli
Aug 23, 2020·Nutrients·Simona DraganRuxandra Christodorescu
Aug 29, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Doratha A ByrdRoberd M Bostick
Feb 23, 2021·European Journal of Nutrition·Kristine K DennisTerryl J Hartman
Jun 23, 2021·Current Opinion in Clinical Nutrition and Metabolic Care·Lina Samira BahrAnja Mähler
Oct 23, 2021·Frontiers in Nutrition·Fatemeh Dehghani FirouzabadiSakineh Shab-Bidar

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