Abstract
Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, accounting for almost 50% of all malignancies in developing nations. Autophagy plays a vital role in cancer initiation, malignant progression, and resistance to treatment. However, autophagy-related gene sets have rarely been analyzed in HNSCC. Hence, it is necessary to assess its clinical and pathological significance in a larger cohort of patients with HNSCC. The purpose of this study was to establish a novel autophagy-related prognostic marker for HNSCC. We screened 232 autophagy-related genes (ARGs) and identified 38 differentially expressed ARGs in The Cancer Genome Atlas (TCGA) cohorts. The prognosis-related ARGs signature, established using the univariate and multivariate Cox proportional regression models, consists of 10 ARGs that could divide patients into high-risk and low-risk groups. Survival analysis indicated that patients in the high-risk group had dramatically shorter overall survival compared with their low-risk counterparts. Cox regression analysis further confirmed the independent prognostic value of the autophagy-related signature, and the area under the receiver operating characteristic curve of the combined prognosti...Continue Reading
References
Mar 27, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F EstebanR Ramírez-Lorca
Feb 4, 2010·Journal of Cancer Research and Clinical Oncology·Hongbing JiangYunong Wu
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Feb 1, 2012·Head & Neck·Benjamin A S GurneyMark McGurk
May 25, 2012·Archives of Gynecology and Obstetrics·Kajohn Achavanuntakul, Kittipat Charoenkwan
Jan 1, 2011·Cancers·Elyse L Walk, Scott A Weed
Apr 17, 2014·Oral Oncology·Boudewijn J M BraakhuisOtto Visser
May 7, 2014·Oral Diseases·Mk SannigrahiM Khullar
Aug 8, 2014·Nature Reviews. Cancer·Florian J SulzmaierDavid D Schlaepfer
Dec 19, 2014·Head & Neck·Jeanne L HatcherKathryn E Weaver
Feb 26, 2015·The EMBO Journal·Lorenzo GalluzziGuido Kroemer
Jul 16, 2015·Nature Reviews. Molecular Cell Biology·Jasvinder Kaur, Jayanta Debnath
Jan 23, 2016·Autophagy·Daniel J KlionskySusu M Zughaier
Jan 30, 2016·Science Advances·Eda MachadoAlessandra d'Azzo
Jan 28, 2017·CA: a Cancer Journal for Clinicians·William M LydiattJatin P Shah
Apr 20, 2018·Cancer·Angelique V OnoratiRavi K Amaravadi
May 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yee Sun TanYu L Lei
Feb 13, 2019·Cancer·Shuo DengAnupam Bishayee
Feb 16, 2019·Cancers·Alfredo Cruz-GregorioMarcela Lizano
Mar 23, 2019·Trends in Cancer·Nilanjana Chatterjee, Trever G Bivona
Jun 27, 2019·Molecular Cancer Research : MCR·Marina Domingo-VidalUbaldo Martinez-Outschoorn
Oct 20, 2019·Cellular Signalling·Li ChenXiao-Yan Zhang
Feb 13, 2020·Cell Discovery·Willa Wen-You Yim, Noboru Mizushima
Citations
Nov 6, 2020·International Journal of Molecular Sciences·Isaac Tamargo-GómezGuillermo Mariño
Jan 16, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zhao DingDeshun Yu
Jan 26, 2021·Frontiers in Genetics·Ergang GuoGuoqing Hu