Development and validation of prognostic index based on autophagy-related genes in patient with head and neck squamous cell carcinoma.

Cell Death Discovery
Hao FengJian Wang

Abstract

Head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers worldwide, accounting for almost 50% of all malignancies in developing nations. Autophagy plays a vital role in cancer initiation, malignant progression, and resistance to treatment. However, autophagy-related gene sets have rarely been analyzed in HNSCC. Hence, it is necessary to assess its clinical and pathological significance in a larger cohort of patients with HNSCC. The purpose of this study was to establish a novel autophagy-related prognostic marker for HNSCC. We screened 232 autophagy-related genes (ARGs) and identified 38 differentially expressed ARGs in The Cancer Genome Atlas (TCGA) cohorts. The prognosis-related ARGs signature, established using the univariate and multivariate Cox proportional regression models, consists of 10 ARGs that could divide patients into high-risk and low-risk groups. Survival analysis indicated that patients in the high-risk group had dramatically shorter overall survival compared with their low-risk counterparts. Cox regression analysis further confirmed the independent prognostic value of the autophagy-related signature, and the area under the receiver operating characteristic curve of the combined prognosti...Continue Reading

References

Mar 27, 2007·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·F EstebanR Ramírez-Lorca
Nov 15, 2011·Cell·Noboru Mizushima, Masaaki Komatsu
Feb 1, 2012·Head & Neck·Benjamin A S GurneyMark McGurk
May 25, 2012·Archives of Gynecology and Obstetrics·Kajohn Achavanuntakul, Kittipat Charoenkwan
May 7, 2014·Oral Diseases·Mk SannigrahiM Khullar
Aug 8, 2014·Nature Reviews. Cancer·Florian J SulzmaierDavid D Schlaepfer
Dec 19, 2014·Head & Neck·Jeanne L HatcherKathryn E Weaver
Feb 26, 2015·The EMBO Journal·Lorenzo GalluzziGuido Kroemer
Jul 16, 2015·Nature Reviews. Molecular Cell Biology·Jasvinder Kaur, Jayanta Debnath
Jan 30, 2016·Science Advances·Eda MachadoAlessandra d'Azzo
Jan 28, 2017·CA: a Cancer Journal for Clinicians·William M LydiattJatin P Shah
Apr 20, 2018·Cancer·Angelique V OnoratiRavi K Amaravadi
May 18, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yee Sun TanYu L Lei
Mar 23, 2019·Trends in Cancer·Nilanjana Chatterjee, Trever G Bivona
Jun 27, 2019·Molecular Cancer Research : MCR·Marina Domingo-VidalUbaldo Martinez-Outschoorn
Feb 13, 2020·Cell Discovery·Willa Wen-You Yim, Noboru Mizushima

❮ Previous
Next ❯

Citations

Nov 6, 2020·International Journal of Molecular Sciences·Isaac Tamargo-GómezGuillermo Mariño
Jan 16, 2021·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Zhao DingDeshun Yu

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE27020

Methods Mentioned

BETA
RNA-seq

Software Mentioned

GOplot
GSEA
R package limma
R language

Related Concepts

Related Feeds

Autophagy & Metabolism

Autophagy preserves the health of cells and tissues by replacing outdated and damaged cellular components with fresh ones. In starvation, it provides an internal source of nutrients for energy generation and, thus, survival. A powerful promoter of metabolic homeostasis at both the cellular and whole-animal level, autophagy prevents degenerative diseases. It does have a downside, however--cancer cells exploit it to survive in nutrient-poor tumors.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Autophagy & Disease

Autophagy is an important cellular process for normal physiology and both elevated and decreased levels of autophagy are associated with disease. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Parkinson's Disease & Autophagy (MDS)

Autophagy leads to degradation of damaged proteins and organelles by the lysosome. Impaired autophagy has been implicated in several diseases. Here is the role of autophagy in Parkinson’s disease.