Abstract
To derive and validate a set of computational models able to assess the risk of developing complications and experiencing adverse events for patients with diabetes. The models are developed on data from the Diabetes Control and Complications Trial (DCCT) and the Epidemiology of Diabetes Interventions and Complications (EDIC) studies, and are validated on an external, retrospectively collected cohort. We selected fifty-one clinical parameters measured at baseline during the DCCT as potential risk factors for the following adverse outcomes: Cardiovascular Diseases (CVD), Hypoglycemia, Ketoacidosis, Microalbuminuria, Proteinuria, Neuropathy and Retinopathy. For each outcome we applied a data-mining analysis protocol in order to identify the best-performing signature, i.e., the smallest set of clinical parameters that, considered jointly, are maximally predictive for the selected outcome. The predictive models built on the selected signatures underwent both an interval validation on the DCCT/EDIC data and an external validation on a retrospective cohort of 393 diabetes patients (49 Type I and 344 Type II) from the Chorleywood Medical Center, UK. The selected predictive signatures contain five to fifteen risk factors, depending on t...Continue Reading
References
Apr 1, 1980·The Journal of Allergy and Clinical Immunology·S R Hirsch, J H Kalbfleisch
Jun 1, 1995·Kidney International
Jan 1, 1995·Archives of Ophthalmology
Apr 15, 1995·Annals of Internal Medicine
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Jan 1, 1993·Diabetes Care·J R SugarmanJ W Hughes
Nov 1, 1995·Diabetes Care
Oct 1, 1996·Annals of Medicine·R C Turner, R R Holman
Feb 28, 1997·Statistics in Medicine·R Tibshirani
Dec 24, 1997·Diabetic Medicine : a Journal of the British Diabetic Association·M EggerP Diem
May 20, 1999·Diabetes Care
Dec 21, 2000·Statistics in Medicine·H C van Houwelingen
Nov 29, 2001·Clinical Science·R J StevensUNKNOWN United Kingdom Prospective Diabetes Study (UKPDS) Group
Feb 5, 2003·Postgraduate Medical Journal·M J FranzJ Bantle
Sep 18, 2004·Bioinformatics·Alexander StatnikovShawn Levy
Nov 2, 2004·Diabetologia·P M ClarkeUNKNOWN UK Prospective Diabetes Study (UKDPS) Group
Aug 13, 2005·Health Technology Assessment : HTA·D J NewmanC Hawke
Sep 7, 2005·Statistics in Medicine·Hans C van HouwelingenLodewyk F A Wessels
Dec 24, 2005·The New England Journal of Medicine·David M NathanUNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research
Jun 8, 2007·Bioinformatics·H M BøvelstadO C Lingjaerde
Oct 14, 2009·Diabetes Technology & Therapeutics·Christian Weber, Oliver Schnell
Nov 13, 2009·Diabetologia·Y VergouweK G M Moons
Apr 28, 2010·Nature Reviews. Clinical Oncology·Jyothi Subramanian, Richard Simon
Jun 4, 2010·Bioinformatics·Vincenzo Lagani, Ioannis Tsamardinos
Sep 9, 2010·Diabetes Care·Morten CharlesUNKNOWN EURODIAB Prospective Complications Study Investigators
Feb 22, 2011·Diabetes Care·M Loredana MarcovecchioDavid B Dunger
Apr 13, 2011·Statistics in Medicine·Hajime UnoL J Wei
Apr 21, 2011·Diabetes Care·Elbert S HuangAndrew J Karter
Mar 22, 2013·Diabetes Care·Maria F Lopes-VirellaUNKNOWN DCCT/EDIC Research Group
Jun 25, 2013·Diabetologia·A J HayesP M Clarke
Jun 26, 2013·Value in Health : the Journal of the International Society for Pharmacoeconomics and Outcomes Research·Andrew J PalmerWilliam Valentine
Jun 27, 2013·Diabetes Care·C Raina ElleyPaul L Drury
Jul 12, 2013·CPT: Pharmacometrics & Systems Pharmacology·I AjmeraV Chelliah
Citations
May 9, 2015·Journal of Diabetes and Its Complications·Vincenzo LaganiIoannis Tsamardinos
Jul 5, 2016·Musculoskeletal Care·Paul A SalamhChad E Cook
Oct 7, 2016·Journal of Diabetes Science and Technology·Rosa Garcia-VerdugoOliver Schnell
Sep 22, 2018·Journal of Pediatric Endocrinology & Metabolism : JPEM·Agnieszka SzadkowskaBeata Mianowska
Aug 23, 2018·Diabetes Care·Lasse BjergDaniel R Witte
Jun 14, 2020·Diabetes Care·An Tran-DuyPhilip M Clarke
Aug 25, 2020·BMC Medical Informatics and Decision Making·Oleg MetskerValeria V Krzhizhanovskaya
Jul 16, 2020·Scientific Reports·Mingyue XueHua Yao
Oct 13, 2018·Current Cardiology Reports·Yanglu Zhao, Nathan D Wong
Jan 18, 2019·Eye·Sajjad HaiderKrishnarajah Nirantharakumar
May 18, 2019·Journal of Medical Systems·Era KimGyorgy J Simon
Oct 22, 2020·BMJ Open Ophthalmology·Sajjad HaiderMalcolm James Price
Feb 1, 2020·Journal of Biomedical Informatics·Sisi MaLisa S Chow
Oct 23, 2018·Computers in Biology and Medicine·Dennis H MurphreeRozalina G McCoy