Development and validation of Spasticity Index-Amyotrophic Lateral Sclerosis

Acta Neurologica Scandinavica
Kristijonas MilinisTONiC Study Group

Abstract

Spasticity is a common and disabling feature of amyotrophic lateral sclerosis (ALS). There are currently no validated ALS-specific measures of spasticity. The aim of this study was to develop and use a self-report outcome measure for spasticity in ALS. Following semi-structured interviews with 11 ALS patients, a draft scale was administered across ALS clinics in the UK. Internal validity of the scale was examined using the Rasch model. The numerical rating scale (NRS) for spasticity and Leeds Spasticity scale (LSS) were co-administered. The final scale was used in a path model of spasticity and quality of life. A total of 465 patients (mean age 64.7 years (SD 10), 59% male) with ALS participated. Spasticity was reported by 80% of subjects. A pool of 71 items representing main themes of physical symptoms, negative impact and modifying factors was subject to an iterative process of item reduction by Rasch analysis resulting in a 20-item scale-the Spasticity Index for ALS (SI-ALS)-which was unidimensional and free from differential item functioning. Moderate correlations were found with LSS and NRS-spasticity. Incorporating the latent estimate of spasticity into a path model, greater spasticity reduced quality of life and motor fu...Continue Reading

References

Jun 25, 2002·Journal of Epidemiology and Community Health·A Bowling
Oct 9, 2004·Multiple Sclerosis : Clinical and Laboratory Research·M A RizzoT L Vollmer
Jan 13, 2006·Archives of Physical Medicine and Rehabilitation·Helga E LechnerPrisca Eser
Nov 2, 2006·Health and Quality of Life Outcomes·Fabio Arpinelli, Francesco Bamfi
Mar 14, 2007·Neurorehabilitation and Neural Repair·Hui-Mei ChenJau-Hong Lin
May 3, 2007·The British Journal of Clinical Psychology·Julie F Pallant, Alan Tennant
Feb 6, 2008·Journal of Rehabilitation Research and Development·Karon F CookArthur M Sherwood
Dec 10, 2008·Spinal Cord·J F FleurenH J Hermens
Sep 19, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·M C McElhineyH Mitsumoto
Mar 22, 2013·Journal of Neurology, Neurosurgery, and Psychiatry·Franco FranchignoniAdriano Chiò
Jun 4, 2013·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Chris GibbonsCarolyn Young
Nov 26, 2013·Topics in Stroke Rehabilitation·Steve BarkerAlan Tennant

❮ Previous
Next ❯

Citations

Nov 6, 2020·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration
Oct 29, 2021·Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration·Carolyn YoungAlan Tennant

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amyloid Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a progressive nervous system disease associated with the death of neurons that control voluntary muscles. Discover the latest research on ALS here.