PMID: 20410573Apr 23, 2010Paper

Development and validation of spectrophotometric methods for estimating amisulpride in pharmaceutical preparations

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Sangita SharmaDipti Dabhi


Five simple, sensitive, accurate and rapid visible spectrophotometric methods (A, B, C, D and E) have been developed for estimating Amisulpride in pharmaceutical preparations. These are based on the diazotization of Amisulpride with sodium nitrite and hydrochloric acid, followed by coupling with N-(1-naphthyl)ethylenediamine dihydrochloride (Method A), diphenylamine (Method B), beta-naphthol in an alkaline medium (Method C), resorcinol in an alkaline medium (Method D) and chromotropic acid in an alkaline medium (Method E) to form a colored chromogen. The absorption maxima, lambda(max), are at 523 nm for Method A, 382 and 490 nm for Method B, 527 nm for Method C, 521 nm for Method D and 486 nm for Method E. Beer's law was obeyed in the concentration range of 2.5-12.5 microg mL(-1) in Method A, 5-25 and 10-50 microg mL(-1) in Method B, 4-20 microg mL(-1) in Method C, 2.5-12.5 microg mL(-1) in Method D and 5-15 microg mL(-1) in Method E. The results obtained for the proposed methods are in good agreement with labeled amounts, when marketed pharmaceutical preparations were analyzed.


Dec 31, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Julia SachseChristoph Hiemke
May 3, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·F PéhourcqB Bégaud
Jul 4, 2007·Journal of Pharmaceutical and Biomedical Analysis·Alessandro MusengaMaria Augusta Raggi

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