Development and validation of spectrophotometric methods for estimation of antimigraine drug eletriptan hydrobromide in pure form and pharmaceutical formulations.

Annales pharmaceutiques françaises
A A GoudaE Saeed

Abstract

The present study aims to develop and validate four simple, sensitive, reproducible, and low-cost spectrophotometric methods for the determination of antimigraine drug (eletriptan hydrobromide) in pure form and pharmaceutical formulations. The methods are based on the formation of yellow colored ion-pair complex between eletriptan hydrobromide and four acid dyes, namely, bromocresol purple (BCP), bromocresol green (BCG), bromophenol blue (BPB), and bromothymol blue (BTB) with absorption maxima at 410, 420, 414 and 416nm, respectively. Several parameters such as pH, buffer type and volume, reagent volume, sequence of addition and effect of extracting solvent were optimized. Under the optimum experimental conditions, beer's law is obeyed over the concentration ranges of 1.0-20 and 1.0-16μgmL-1 for (BCP or BCG) and (BPB or BTB), respectively with good correlation coefficients (0.9995-0.9999). The apparent molar absorptivity and Sandell's sensitivity values are reported for all methods. The limit of detection (LOD) and the limit of quantification (LOQ) values are found to be 0.27, 0.28, 0.25, and 0.30μgmL-1 and 0.90, 0.93, 0.83, and 1.0μgmL-1 for BCP, BCG, BPB and BTB, respectively. The stoichiometric ratio of the formed ion-pair c...Continue Reading

References

Jun 20, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·David C EvansRichard Hargreaves
Nov 23, 2006·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Alaa S AminFaten Zahran
Oct 30, 2007·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Ayman A GoudaRham El-Azzazy
Mar 3, 2009·Journal of Pharmaceutical and Biomedical Analysis·Biljana JocićVlatka Vajs

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