Development and validation of subject-specific finite element models for blunt trauma study

Journal of Biomechanical Engineering
Weixin ShenJames H Stuhmiller

Abstract

This study developed and validated finite element (FE) models of swine and human thoraxes and abdomens that had subject-specific anatomies and could accurately and efficiently predict body responses to blunt impacts. Anatomies of the rib cage, torso walls, thoracic, and abdominal organs were reconstructed from X-ray computed tomography (CT) images and extracted into geometries to build FE meshes. The rib cage was modeled as an inhomogeneous beam structure with geometry and bone material parameters determined directly from CT images. Meshes of soft components were generated by mapping structured mesh templates representative of organ topologies onto the geometries. The swine models were developed from and validated by 30 animal tests in which blunt insults were applied to swine subjects and CT images, chest wall motions, lung pressures, and pathological data were acquired. A comparison of the FE calculations of animal responses and experimental measurements showed a good agreement. The errors in calculated response time traces were within 10% for most tests. Calculated peak responses showed strong correlations with the experimental values. The stress concentration inside the ribs, lungs, and livers produced by FE simulations als...Continue Reading

References

Jan 1, 1977·Journal of Biomechanics·S H Sundaram, C C Feng
Jan 1, 1975·Journal of Biomechanics·D T Reilly, A H Burstein
May 1, 1992·Journal of Biomechanics·R F CloskeyC W Luchies
Jan 1, 1991·Journal of Biomechanics·S A GoldsteinS J Hollister
Dec 1, 1989·Accident; Analysis and Prevention·D C VianoP Begeman
Feb 1, 1988·Journal of Biomechanical Engineering·Y C FungS Q Liu
Nov 1, 1974·Journal of Biomechanics·T AndriacchiJ Galante
Feb 1, 1974·The American Journal of Physiology·X T Truong
Jan 1, 1974·Journal of Biomechanics·Y Lanir, Y C Fung
May 1, 1984·Journal of Biomechanical Engineering·A I King
Feb 1, 1980·Journal of Biomechanical Engineering·D L Vawter
Jul 1, 1995·Medical Engineering & Physics·J Y RhoR B Ashman
May 1, 1994·Journal of Biomechanical Engineering·Y HuangJ M Cavanaugh
Nov 1, 1993·Journal of Biomechanical Engineering·A I King
Feb 1, 1996·Journal of Biomechanics·J H StuhmillerM Mayorga
Feb 24, 2001·Journal of Biomechanical Engineering·N YoganandanF A Pintar
May 22, 2002·Journal of Biomechanics·W R TaylorS E Clift
Mar 16, 2004·Medicine, Conflict, and Survival·Brian Rappert
Mar 12, 2005·The Journal of Trauma·Weixin ShenJames H Stuhmiller
Oct 19, 2006·Medical Engineering & Physics·Yuqing NiuJames H Stuhmiller

❮ Previous
Next ❯

Citations

Apr 24, 2010·Medical & Biological Engineering & Computing·E JolivetW Skalli
Dec 15, 2010·Journal of Biomechanical Engineering·Weixin ShenNorman Link
Dec 19, 2012·Computer Methods and Programs in Biomedicine·Sébastien RothKarine Thoral-Pierre
Nov 5, 2011·Medical Engineering & Physics·Jason J HallmanFrank A Pintar
Oct 19, 2011·Facial Plastic Surgery Clinics of North America·Edoardo Mazza, Giuseppe Giovanni Barbarino
Apr 3, 2009·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Zbynĕk TonarFrantisek Zátura
Jun 2, 2015·Traffic Injury Prevention·Samantha L SchoellJoel D Stitzel
Nov 20, 2018·Computer Methods in Biomechanics and Biomedical Engineering·Benedikt SchlagerHans-Joachim Wilke
Nov 21, 2014·Journal of Biomechanical Engineering·Melissa M GibbonsPhilemon C Chan
Jul 1, 2020·Biomechanics and Modeling in Mechanobiology·J D Clayton
Aug 19, 2020·Journal of Biomechanics·Blake JohnsonNaira Campbell-Kyureghyan
May 10, 2020·Medical Engineering & Physics·Blake JohnsonNaira Campbell-Kyureghyan
Apr 20, 2021·Forensic Science International : Synergy·Shaomin LuoJuan Li

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.