Abstract
A subtype prediction score for primary aldosteronism has not yet been developed and validated using a large dataset. This study aimed to develop and validate a new subtype prediction score and to compare it with existing scores using a large multicenter database. In total, 1936 patients with primary aldosteronism were randomly assigned to the development and validation datasets, constituting 1290 and 646 patients, respectively. Three prediction scores were generated with or without confirmatory tests, using logistic regression analysis. In the validation dataset, new and existing prediction scores were compared using receiver operating characteristic curve, net reclassification improvement, and integrated discrimination improvement analyses. The new prediction score is simply calculated using serum potassium levels [>3.9 mmol/l (four points); 3.5-3.9 mmol/l (three points)], the absence of adrenal nodules during computed tomography (three points), a baseline plasma aldosterone concentration of <210.0 pg/ml (two points), a baseline aldosterone/renin ratio of less than 620 (two points), and female sex (one point). Using the validation dataset, we found that a new subtype prediction score of at least 8 had a positive predictive val...Continue Reading
References
Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroWilliam F Young
Jan 20, 2005·Surgery·William F YoungJon A van Heerden
Apr 20, 2005·Journal of the American College of Cardiology·Paul MilliezJean-Jacques Mourad
Oct 18, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nicholas Daunt
Mar 2, 2006·Journal of Hypertension·Gian Paolo RossiAchille C Pessina
Feb 21, 2007·Circulation·Nancy R Cook
Jan 16, 2008·Archives of Internal Medicine·Cristiana CatenaLeonardo A Sechi
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Sep 2, 2009·Annals of Internal Medicine·Marlies J E KempersJaap Deinum
Aug 11, 2011·Endocrine Journal·Tetsuo NishikawaUNKNOWN Task Force Committee on Primary Aldosteronism, The Japan Endocrine Society
Aug 25, 2012·The Journal of Clinical Endocrinology and Metabolism·Elselien M KüpersOlivier Steichen
Jun 12, 2013·Hypertension·Sébastien SavardOlivier Steichen
Aug 16, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoYusuke Ohya
Sep 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroFranco Veglio
Nov 13, 2013·Hypertension·Gian Paolo RossiWilliam F Young
Apr 4, 2014·Journal of Human Hypertension·K NanbaM Naruse
Apr 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoUNKNOWN Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
May 2, 2015·Endocrine·Kazutaka NanbaMitsuhide Naruse
Nov 27, 2015·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M-C ZennaroX Jeunemaitre
Dec 15, 2015·Clinical Endocrinology·Hiroki KobayashiMasayoshi Soma
Jan 21, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tomaz KocjanMojca Jensterle
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·John W FunderWilliam F Young
May 24, 2016·Clinical Endocrinology·Martin J WolleyMichael Stowasser
Sep 2, 2016·Journal of Human Hypertension·K KamemuraM Naruse
Nov 20, 2016·Clinical Endocrinology·Hiroki KobayashiMasayoshi Soma
Apr 8, 2017·Journal of the American College of Cardiology·Silvia MonticonePaolo Mulatero
Oct 4, 2017·Endocrine Reviews·Maria-Christina ZennaroFabio Fernandes-Rosa
Citations
Jun 25, 2019·Hypertension·Hiroshi AkasakaUNKNOWN Japan Primary Aldosteronism Study Group *
Apr 30, 2019·Journal of Hypertension·Motonori NagasawaUNKNOWN JPAS Study Group
Dec 19, 2019·Journal of Hypertension·Troy H PuarPeng C Kek
Oct 19, 2019·Clinical Case Reports·Ryo NakamaruHiromi Rakugi
May 30, 2020·Journal of Diabetes Investigation·Mikiko Okazaki-HadaHitoshi Sugihara
Jun 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Jacopo BurrelloPaolo Mulatero
Oct 23, 2019·Journal of the Endocrine Society·Mitsuha MorisakiUNKNOWN JPAS Study Group
Oct 9, 2020·The Journal of Clinical Endocrinology and Metabolism·Youichi OhnoAkiyo Tanabe
Dec 29, 2020·Hypertension·Ryo NakamaruUNKNOWN JPAS/JRAS study group
Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Adina F Turcu, Richard Auchus
Aug 28, 2020·Endocrine Journal·Norio WadaShinji Obara
Mar 30, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Bin LiuUNKNOWN Chongqing Primary Aldosteronism Study (CONPASS) Group
Apr 1, 2021·Endocrinology and Metabolism·Seung Hun LeeJung Hee Kim
Apr 25, 2020·Journal of the American College of Cardiology·Zhixin XuUNKNOWN Chongqing Primary Aldosteronism Study (CONPASS) Group
Apr 25, 2020·Journal of the American College of Cardiology·John W Funder
Apr 30, 2021·Frontiers in Endocrinology·Kentaro OkamotoMitsuhide Naruse
May 6, 2021·Scientific Reports·Hiroki KanekoYoshihiro Ogawa
Jul 27, 2021·Frontiers in Oncology·Keng HeXin-Lan Xiao
Sep 3, 2021·Endocrinology and Metabolism·Seung Hun LeeJung Hee Kim
Oct 23, 2021·Endocrinology and Metabolism·Mitsuhide NaruseMasakatsu Sone
Dec 28, 2021·American Journal of Hypertension·D SamA A Leung