Development and validation of subtype prediction scores for the workup of primary aldosteronism

Journal of Hypertension
Hiroki KobayashiJPAS Study Group

Abstract

A subtype prediction score for primary aldosteronism has not yet been developed and validated using a large dataset. This study aimed to develop and validate a new subtype prediction score and to compare it with existing scores using a large multicenter database. In total, 1936 patients with primary aldosteronism were randomly assigned to the development and validation datasets, constituting 1290 and 646 patients, respectively. Three prediction scores were generated with or without confirmatory tests, using logistic regression analysis. In the validation dataset, new and existing prediction scores were compared using receiver operating characteristic curve, net reclassification improvement, and integrated discrimination improvement analyses. The new prediction score is simply calculated using serum potassium levels [>3.9 mmol/l (four points); 3.5-3.9 mmol/l (three points)], the absence of adrenal nodules during computed tomography (three points), a baseline plasma aldosterone concentration of <210.0 pg/ml (two points), a baseline aldosterone/renin ratio of less than 620 (two points), and female sex (one point). Using the validation dataset, we found that a new subtype prediction score of at least 8 had a positive predictive val...Continue Reading

References

Mar 6, 2004·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroWilliam F Young
Jan 20, 2005·Surgery·William F YoungJon A van Heerden
Apr 20, 2005·Journal of the American College of Cardiology·Paul MilliezJean-Jacques Mourad
Oct 18, 2005·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Nicholas Daunt
Jan 16, 2008·Archives of Internal Medicine·Cristiana CatenaLeonardo A Sechi
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Seiichi MatsuoUNKNOWN Collaborators developing the Japanese equation for estimated GFR
Aug 11, 2011·Endocrine Journal·Tetsuo NishikawaUNKNOWN Task Force Committee on Primary Aldosteronism, The Japan Endocrine Society
Aug 25, 2012·The Journal of Clinical Endocrinology and Metabolism·Elselien M KüpersOlivier Steichen
Sep 24, 2013·The Journal of Clinical Endocrinology and Metabolism·Paolo MulateroFranco Veglio
Apr 4, 2014·Journal of Human Hypertension·K NanbaM Naruse
Apr 8, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Kazuaki ShimamotoUNKNOWN Japanese Society of Hypertension Committee for Guidelines for the Management of Hypertension
May 2, 2015·Endocrine·Kazutaka NanbaMitsuhide Naruse
Nov 27, 2015·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M-C ZennaroX Jeunemaitre
Jan 21, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Tomaz KocjanMojca Jensterle
Mar 5, 2016·The Journal of Clinical Endocrinology and Metabolism·John W FunderWilliam F Young
Apr 8, 2017·Journal of the American College of Cardiology·Silvia MonticonePaolo Mulatero
Oct 4, 2017·Endocrine Reviews·Maria-Christina ZennaroFabio Fernandes-Rosa

❮ Previous
Next ❯

Citations

Jun 25, 2019·Hypertension·Hiroshi AkasakaUNKNOWN Japan Primary Aldosteronism Study Group *
Apr 30, 2019·Journal of Hypertension·Motonori NagasawaUNKNOWN JPAS Study Group
Dec 19, 2019·Journal of Hypertension·Troy H PuarPeng C Kek
Jun 21, 2020·The Journal of Clinical Endocrinology and Metabolism·Jacopo BurrelloPaolo Mulatero
Oct 23, 2019·Journal of the Endocrine Society·Mitsuha MorisakiUNKNOWN JPAS Study Group
Oct 9, 2020·The Journal of Clinical Endocrinology and Metabolism·Youichi OhnoAkiyo Tanabe
Dec 29, 2020·Hypertension·Ryo NakamaruUNKNOWN JPAS/JRAS study group
Jan 1, 2021·The Journal of Clinical Endocrinology and Metabolism·Adina F Turcu, Richard Auchus
Mar 30, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Bin LiuUNKNOWN Chongqing Primary Aldosteronism Study (CONPASS) Group
Apr 25, 2020·Journal of the American College of Cardiology·Zhixin XuUNKNOWN Chongqing Primary Aldosteronism Study (CONPASS) Group
Apr 25, 2020·Journal of the American College of Cardiology·John W Funder
Apr 30, 2021·Frontiers in Endocrinology·Kentaro OkamotoMitsuhide Naruse
Oct 23, 2021·Endocrinology and Metabolism·Mitsuhide NaruseMasakatsu Sone
Dec 28, 2021·American Journal of Hypertension·D SamA A Leung

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.