Development and Validation of Web-Based Nomograms to Precisely Predict Conditional Risk of Site-Specific Recurrence for Patients With Completely Resected Non-small Cell Lung Cancer: A Multiinstitutional Study

Chest
Yang ZhangHaiquan Chen

Abstract

There is currently no consensus regarding the optimal postoperative follow-up strategy for patients with completely resected non-small cell lung cancer (NSCLC). We aimed to develop web-based nomograms to precisely predict site-specific postoperative recurrence in patients with NSCLC and to guide individual surveillance strategies including when to follow up and what diagnostic tests to perform. We investigated the pattern of recurrence in a series of 2,017 patients with NSCLC (squamous cell carcinoma and nonlepidic invasive adenocarcinoma) who underwent complete surgical resection at Fudan University Shanghai Cancer Center (development cohort), and developed web-based clinicopathologic prediction models for conditional risk of site-specific recurrence based on Cox regression. The variables used in the analysis included sex, age, smoking history, tumor size, tumor histology, lymphovascular invasion, visceral pleural invasion, and pathologic TNM stage. A separate cohort of 3,308 patients with NSCLC from Shanghai Chest Hospital was used for external validation. In the development cohort and the external validation cohort for the established nomograms to predict overall recurrence, thorax recurrence, abdomen recurrence, neck recurr...Continue Reading

Citations

Nov 8, 2018·Korean Circulation Journal·Boyoung JoungUNKNOWN KHRS Atrial Fibrillation Guideline Working Group
Mar 18, 2020·International Journal of Cancer. Journal International Du Cancer·Fangqiu FuHaiquan Chen
May 26, 2020·Seminars in Thoracic and Cardiovascular Surgery·Yue ZhaoHaiquan Chen
Mar 12, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Guangyao WuPhilippe Lambin
Jun 27, 2021·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Chaoqiang DengHaiquan Chen
Jun 15, 2021·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·Fan WangFengsen Li

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