Development, commissioning, and evaluation of a new intensity modulated minibeam proton therapy system

Medical Physics
J B FarrW Yao

Abstract

To invent, design, construct, and commission an intensity modulated minibeam proton therapy system (IMMPT) without the need for physical collimation and to compare its resulting conformity to a conventional IMPT system. A proton therapy system (Hitachi, Ltd, Hitachi City, Japan; Model: Probeat-V) was specially modified to produce scanned minibeams without collimation. We performed integral depth dose acquisitions and calibrations using a large diameter parallel-plate ionization chamber in a scanning water phantom (PTW, Freiburg, Germany; Models: Bragg Peak ionization chamber, MP3-P). Spot size and shape was measured using radiochromic film (Ashland Advanced Materials, Bridgewater NJ; Type: EBT3), and a synthetic diamond diode type scanned point by point in air (PTW Models: MicroDiamond, MP3-P). The measured data were used as inputs to generate a Monte Carlo-based model for a commercial radiotherapy planning system (TPS) (Varian Medical Systems, Inc., Palo Alto, CA; Model: Eclipse v13.7.15). The regular ProBeat-V system (sigma ~2.5 mm) TPS model was available for comparison. A simulated base of skull case with small and medium targets proximal to brainstem was planned for both systems and compared. The spot sigma is determined t...Continue Reading

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Citations

Oct 26, 2018·The British Journal of Radiology·Juergen MeyerYolanda Prezado
Nov 14, 2018·Medical Physics·Jonathan B FarrMichael F Moyers
May 27, 2020·Journal of Applied Clinical Medical Physics·Maduka KaluarachchiAustin M Faught
Feb 20, 2021·Physics in Medicine and Biology·Lydia J WilsonAustin M Faught

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