PMID: 19130628Jan 9, 2009Paper

Development-dependent expression of calreticulin in the brain and other tissues of the Japanese monkey, Macaca fuscata

Journal of Medical Primatology
A Higashino, T Kageyama

Abstract

Calreticulin (CRT) is a molecular chaperone localized to endoplasmic reticulum lumen. The protein is involved in the correct folding of glycoproteins and its cellular level changes depending on various physiologic conditions. To clarify the Crt level in various tissues of the Japanese monkey during postnatal development, an enzyme-linked immunosorbent assay system that we have established was applied. Calreticulin is distributed ubiquitously in various tissues. Its level in the heart, lung, liver, spleen, and kidney was high in newborns and decreased in juveniles and adults. In various cerebral areas, Crt was present in the gray matter but scarcely found in the white matter. The Crt levels in the cerebral areas were low in newborns and increased in juveniles and adults. These distribution and developmental changes in Crt might be correlated with the quality control of glycoproteins that are synthesized in respective tissues.

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Citations

Apr 18, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·M OhadiH Darvish
Sep 18, 2009·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M Olad NabiM Ohadi
Jul 5, 2011·Progress in Neuro-psychopharmacology & Biological Psychiatry·E Esmaeilzadeh-GharehdaghiM Ohadi
Dec 25, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·T FarokhashtianiM Ohadi
Oct 3, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Christian Harteneck
Oct 1, 2013·Pharmacological Reviews·Deepak P SrivastavaPeter Penzes
Feb 27, 2015·Hormone Molecular Biology and Clinical Investigation·Richard HamplLucie Sosvorová

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