Development, in vitro validation and human application of a novel method to identify arrhythmia mechanisms: The stochastic trajectory analysis of ranked signals mapping method.

Journal of Cardiovascular Electrophysiology
Shohreh HonarbakhshRichard J Schilling

Abstract

Stochastic trajectory analysis of ranked signals (STAR) is a novel method for mapping arrhythmia. The aim was to describe its development and validation as a mapping tool. The method ranks electrodes in terms of the proportion of the time they lead relative to neighboring electrodes and ascribes a predominant direction of activation between electrodes. This was conceived with the aim of mapping atrial fibrillation (AF) drivers. Validation of this approach was performed in stages. First, in vitro simultaneous multi-electrode array and optical mapping were performed on spontaneously fibrillating HL1 cell cultures, to determine if such a method would be able to determine early sites of activation (ESA). A clinical study acquiring unipolar electrograms using a 64-pole basket for the purposes of STAR mapping in patients undergoing atrial tachycardia (AT) ablation. STAR maps were analyzed by physicians to see if arrhythmia mechanisms could be correctly determined. Mapping was then repeated during atrial pacing. STAR mapping of in vitro activation sequences accurately correlated to the optical maps of planar and rotational activation. Thirty-two ATs were mapped in 25 patients. The ESA accurately identified focal/micro-reentrant ATs an...Continue Reading

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Citations

Sep 26, 2019·Journal of Cardiovascular Electrophysiology·Shohreh HonarbakhshRoss J Hunter
Sep 26, 2019·Frontiers in Physiology·Nele VandersickelAlexander V Panfilov
Jul 2, 2020·Bioengineering·Amirhossein KoneshlooYuncheng Du
Sep 10, 2020·Circulation. Arrhythmia and Electrophysiology·Shohreh HonarbakhshRoss J Hunter
Feb 23, 2020·JACC. Clinical Electrophysiology·Atul Verma, Sanjiv M Narayan
May 7, 2021·Journal of Cardiovascular Electrophysiology·Miguel Rodrigo, Sanjiv M Narayan
Jul 20, 2019·JACC. Clinical Electrophysiology·Shohreh HonarbakhshRichard J Schilling

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