PMID: 9160975Apr 24, 1997Paper

Development neurobiology of the stress response: multilevel regulation of corticotropin-releasing hormone function

Annals of the New York Academy of Sciences
T Z BaramL Schultz

Abstract

The ability to respond to adverse environmental cues is present in the neonatal and infant rat, although in an immature form: A number of laboratories have demonstrated stress-induced elevations of plasma glucocorticoids during the first two postnatal weeks. The limbic and hypothalamic mechanisms controlling the hormonal stress-response during this period are not fully understood and are, therefore, the focus of this report. Both hypothalamic corticotropin-releasing hormone (CRH) and vasopressin contribute to the release of ACTH from the pituitary in the adult. The relative roles of these two peptides during the neonatal (first week) and infant (second week) developmental period, are controversial. Evidence is presented that argues strongly for a major role for CRH. Up-regulation of hypothalamic CRH synthesis is a major component in the mature stress response. CRH-mRNA levels in the hypothalamic PVN are increased with cold stress by ninth postnatal day, but not during the first postnatal week. Further, down-regulation of CRH gene expression by glucocorticoids (GC) constitutes a critical "shut-down" mechanism for the hormonal stress response. In vivo and in vitro experiments supporting the "immaturity" of GC feedback on CRH synt...Continue Reading

References

Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T Z Baram, S P Lerner
Sep 1, 1989·The Journal of Endocrinology·M S Harbuz, S L Lightman
Jun 2, 1995·Neuroscience Letters·M UchiyamaK Meier-Ewert
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·T W LovenbergT Oltersdorf
Oct 1, 1993·Journal of Pharmacological and Toxicological Methods·S J Yi, T Z Baram
Feb 26, 1996·Brain Research. Developmental Brain Research·S Avishai-ElinerT Z Baram

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Citations

Mar 15, 2003·Obstetrics and Gynecology·T M Siler-KhodrG Khodr
Nov 13, 2001·Behavioural Brain Research·C P Wiedenmayer, G A Barr
Mar 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristina A FenoglioTallie Z Baram
Apr 9, 2014·Frontiers in Endocrinology·Millie Rincón-Cortés, Regina M Sullivan
Nov 17, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stephen C Heinrichs
Oct 24, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T DubéT Z Baram

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