Development of 4D mathematical observer models for the task-based evaluation of gated myocardial perfusion SPECT

Physics in Medicine and Biology
Taek-Soo LeeBenjamin M W Tsui

Abstract

This paper presents two 4D mathematical observer models for the detection of motion defects in 4D gated medical images. Their performance was compared with results from human observers in detecting a regional motion abnormality in simulated 4D gated myocardial perfusion (MP) SPECT images. The first 4D mathematical observer model extends the conventional channelized Hotelling observer (CHO) based on a set of 2D spatial channels and the second is a proposed model that uses a set of 4D space-time channels. Simulated projection data were generated using the 4D NURBS-based cardiac-torso (NCAT) phantom with 16 gates/cardiac cycle. The activity distribution modelled uptake of (99m)Tc MIBI with normal perfusion and a regional wall motion defect. An analytical projector was used in the simulation and the filtered backprojection (FBP) algorithm was used in image reconstruction followed by spatial and temporal low-pass filtering with various cut-off frequencies. Then, we extracted 2D image slices from each time frame and reorganized them into a set of cine images. For the first model, we applied 2D spatial channels to the cine images and generated a set of feature vectors that were stacked for the images from different slices of the heart...Continue Reading

References

Oct 1, 1978·Seminars in Nuclear Medicine·C E Metz
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Nov 26, 2010·Medical Physics·Thibault Marin, Jovan G Brankov

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Citations

Feb 7, 2019·Physics in Medicine and Biology·Jing Wu, Chi Liu

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