PMID: 9440847Jan 24, 1998Paper

Development of a biodegradable ureteric stent: surface modification and in vitro assessment

Journal of Endourology
A BrauersG Jakse

Abstract

The aim of the present study was to develop a short bioresorbable ureteric stent and to characterize the chosen polymers with respect to surface modification, biocompatibility, and loading of a biologically active compound. As materials for the stent, poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) were chosen. Degradation experiments were carried out and analytical data were obtained by contact angle measurement, X-ray photoelectron spectroscopy (XPS), and infrared spectroscopy in the attenuated reflection mode (FTIR-ATR). Gas loading technology was used to incorporate biologically active compounds, and biocompatibility of the polymers was assessed by in vitro cellular assays, applying measures such as cell morphology, proliferative activity, and membrane integrity. Our results indicate that surface modification of bioresorbable polymers is a suitable and efficient approach to improve the surface properties. Incorporation of biologically active compounds was possible without loss of activity, and in vitro assessment of cellular responses demonstrated the biocompatibility of the chosen polymers and modifications.

References

Jun 1, 1994·British Journal of Urology·P F KeaneS P Gorman
May 1, 1993·Urological Research·E KemppainenO Alfthan
Aug 1, 1996·Biomaterials·M M TunneyS P Gorman

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Citations

Oct 3, 2006·Urology·Omid C FarokhzadRobert Langer
Mar 12, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Meital ZilbermanRobert C Eberhart
Jan 10, 2003·Journal of Biomaterials Science. Polymer Edition·M ZilbermanN D Schwade
Jul 2, 2005·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Meital ZilbermanRobert C Eberhart
May 16, 2003·Journal of Biomaterials Science. Polymer Edition·Robert C EberhartPeter Frenkel

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