Development of a biofilm inhibitor molecule against multidrug resistant Staphylococcus aureus associated with gestational urinary tract infections

Frontiers in Microbiology
P BalamuruganS Adline Princy

Abstract

Urinary Tract Infection (UTI) is a globally widespread human infection caused by an infestation of uropathogens. Eventhough, Escherichia coli is often quoted as being the chief among them, Staphylococcus aureus involvement in UTI especially in gestational UTI is often understated. Staphylococcal accessory regulator A (SarA) is a quorum regulator of S. aureus that controls the expression of various virulence and biofilm phenotypes. Since SarA had been a focussed target for antibiofilm agent development, the study aims to develop a potential drug molecule targeting the SarA of S. aureus to combat biofilm associated infections in which it is involved. In our previous studies, we have reported the antibiofilm activity of SarA based biofilm inhibitor, (SarABI) with a 50% minimum biofilm inhibitory concentration (MBIC50) value of 200 μg/mL against S. aureus associated with vascular graft infections and also the antibiofilm activity of the root ethanolic extracts of Melia dubia against uropathogenic E. coli. In the present study, in silico design of a hybrid molecule composed of a molecule screened from M. dubia root ethanolic extracts and a modified SarA based inhibitor (SarABI(M)) was undertaken. SarABI(M) is a modified form of SarA...Continue Reading

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Citations

Apr 20, 2016·Frontiers in Microbiology·Guyue ChengZonghui Yuan
Feb 20, 2018·Applied Microbiology and Biotechnology·Lasse van GeelenRainer Kalscheuer
Dec 21, 2017·Frontiers in Cellular and Infection Microbiology·Ramanathan SrinivasanArumugam Veera Ravi
Apr 17, 2019·Frontiers in Microbiology·Mansura S MulaniKarishma R Pardesi
Sep 26, 2019·Frontiers in Microbiology·Anthonymuthu SelvarajShunmugiah Karutha Pandian
Aug 28, 2020·Frontiers in Microbiology·Alaguvel ValliammaiShunmugiah Karutha Pandian

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Methods Mentioned

BETA
in silico techniques
ELISA

Software Mentioned

GraphPad prism
Schrödinger
LigPrep
Chemsketch
Schrödinger Suite
[UNK] Discovery
Topkat
[UNK] Suite
GraphPad

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