Development of a biological scaffold engineered using the extracellular matrix secreted by skeletal muscle cells

Biomaterials
Shiloh A HurdJeffrey C Wolchok

Abstract

The performance of implantable biomaterials derived from decellularized tissue, including encouraging results with skeletal muscle, suggests that the extracellular matrix (ECM) derived from native tissue has promising regenerative potential. Yet, the supply of biomaterials derived from donated tissue will always be limited, which is why the in-vitro fabrication of ECM biomaterials that mimic the properties of tissue is an attractive alternative. Towards this end, our group has utilized a novel method to collect the ECM that skeletal muscle myoblasts secrete and form it into implantable scaffolds. The cell derived ECM contained several matrix constituents, including collagen and fibronectin that were also identified within skeletal muscle samples. The ECM was organized into a porous network that could be formed with the elongated and aligned architecture observed within muscle samples. The ECM material supported the attachment and in-vitro proliferation of cells, suggesting effectiveness for cell transplantation, and was well tolerated by the host when examined in-vivo. The results suggest that the ECM collection approach can be used to produce biomaterials with compositions and structures that are similar to muscle samples, and...Continue Reading

References

Jan 1, 1991·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R R MillerB W Festoff
Jul 16, 1985·Biochemical and Biophysical Research Communications·J S RaoB W Festoff
Jun 10, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·C A Edwards, W D O'Brien
Aug 2, 2003·Journal of Anatomy·Maria HillG Goldspink
Feb 1, 1961·The Journal of Biophysical and Biochemical Cytology·A MAURO
May 4, 2007·American Journal of Physiology. Cell Physiology·Catherine AlexakisGeorge Bou-Gharios
Dec 17, 2008·Biomaterials·Weining Bian, Nenad Bursac
Feb 24, 2009·The Annals of Thoracic Surgery·Agathe SeguinEmmanuel Martinod
Nov 17, 2009·Sports Medicine and Arthroscopy Review·David A McGuire, Stephen D Hendricks
Jan 16, 2010·Cell and Tissue Banking·Jorge Leon-VillapalosPeter Dziewulski
Jun 9, 2010·Techniques in Hand & Upper Extremity Surgery·Scott N Oishi, Marybeth Ezaki
Jul 3, 2010·Journal of Biomedical Materials Research. Part a·Shawn C Owen, Molly S Shoichet
Jul 17, 2010·Journal of Applied Physiology·Chau-Zen WangChia-Hsin Chen
Jul 20, 2010·Biomaterials·Jolene E ValentinStephen F Badylak
Jun 15, 2011·Cell Transplantation·Anabel S de la Garza-RodeaShoshan Knaän-Shanzer
Sep 1, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jacob KofflerShulamit Levenberg
Oct 26, 2011·Cells, Tissues, Organs·John M WainwrightStephen F Badylak
Jan 24, 2012·Biomaterials·Matthew T WolfStephen F Badylak
Sep 5, 2012·Indian Journal of Ophthalmology·Matthew S OlivaManoj Gulati
Feb 26, 2013·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Mustafa RamazanogluKarl Andreas Schlegel
Jun 26, 2013·Annals of Biomedical Engineering·Jeffrey C Wolchok, Patrick A Tresco
Jul 26, 2013·American Journal of Physiology. Cell Physiology·B T CoronaC R Rathbone

❮ Previous
Next ❯

Citations

Jul 30, 2015·Acta Biomaterialia·Jonathan M GrasmanGeorge D Pins
Jun 22, 2016·Journal of Materials Science. Materials in Medicine·Klaire WilsonJeffrey C Wolchok
Jul 21, 2016·Experimental Gerontology·John T KimJeffrey C Wolchok
Jul 28, 2016·Journal of Orthopaedic Surgery and Research·Claudia FuocoCesare Gargioli
Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Marek KaweckiAleksandra Kasperczyk
Sep 1, 2017·Biomedical Materials·Kevin RobertsJeffrey C Wolchok
Jan 1, 2016·Acta Medica (Hradec Králové)·Hana HrebíkováJaroslav Mokrý
Feb 8, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Francesca GattazzoPaolo Bonaldo
Aug 8, 2020·Advanced Healthcare Materials·Min BaoWilhelm T S Huck
Mar 10, 2017·Seminars in Immunology·Aaron H MorrisT R Kyriakides
Jan 25, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Takashi Hoshiba, Natsumi Yokoyama
Jun 5, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Chunqing MengTingfang Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.

Related Papers

Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
William Bonfield
Nanomedicine : Nanotechnology, Biology, and Medicine
Dong Han, Pelagia-Irene Gouma
© 2022 Meta ULC. All rights reserved