Development of a Center for Personalized Cancer Care at a Regional Cancer Center: Feasibility Trial of an Institutional Tumor Sequencing Advisory Board

The Journal of Molecular Diagnostics : JMD
Brian R LaneSpectrum Health Tumor Sequencing Advisory Board

Abstract

Next-generation sequencing (NGS) capabilities can affect therapeutic decisions in patients with complex, advanced, or refractory cancer. We report the feasibility of a tumor sequencing advisory board at a regional cancer center. Specimens were analyzed for approximately 2800 mutations in 50 genes. Outcomes of interest included tumor sequencing advisory board function and processes, timely discussion of results, and proportion of reports having potentially actionable mutations. NGS results were successfully generated for 15 patients, with median time from tissue processing to reporting of 11.6 days (range, 5 to 21 days), and presented at a biweekly multidisciplinary tumor sequencing advisory board. Attendance averaged 19 participants (range, 12 to 24) at 20 days after patient enrollment (range, 10 to 30 days). Twenty-seven (range, 1 to 4 per patient) potentially actionable mutations were detected in 11 of 15 patients: TP53 (n = 6), KRAS (n = 4), MET (n = 3), APC (n = 3), CDKN2A (n = 2), PTEN (n = 2), PIK3CA, FLT3, NRAS, VHL, BRAF, SMAD4, and ATM. The Hotspot Panel is now offered as a clinically available test at our institution. NGS results can be obtained by in-house high-throughput sequencing and reviewed in a multidisciplinar...Continue Reading

References

Apr 6, 1999·The Journal of Experimental Medicine·V Lallemand-BreitenbachH de Thé
Jun 25, 2010·The New England Journal of Medicine·Makoto MaemondoUNKNOWN North-East Japan Study Group
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel D Von HoffRobert Penny
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Dec 3, 2011·Science Translational Medicine·Sameek RoychowdhuryArul M Chinnaiyan
Sep 6, 2012·International Journal of Cancer. Journal International Du Cancer·Ben TranJanet E Dancey
Sep 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Apostolia-Maria TsimberidouRazelle Kurzrock
Nov 10, 2012·Nature Biotechnology·Amy S GargisIra M Lubin
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Levi A GarrawayKarla V Ballman
Apr 17, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Funda Meric-BernstamGordon B Mills
Jun 22, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Robert C GreenUNKNOWN American College of Medical Genetics and Genomics
Jul 28, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Heidi L RehmUNKNOWN Working Group of the American College of Medical Genetics and Genomics Laboratory Quality Assurance Commitee
Dec 18, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Gregory J TsongalisChristopher I Amos
Jan 23, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Zsofia K StadlerKenneth Offit
Mar 19, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Elena GarraldaManuel Hidalgo
Mar 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stacy W GrayJane C Weeks
May 7, 2014·The Oncologist·Maria SchwaederleRazelle Kurzrock
Jun 25, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D Williams ParsonsArul M Chinnaiyan
Aug 16, 2014·International Journal of Cancer. Journal International Du Cancer·Daniel V T CatenacciOlufunmilayo I Olopade
Oct 31, 2014·Nucleic Acids Research·Simon A ForbesPeter J Campbell
Aug 6, 2015·The New England Journal of Medicine·Christopher J SweeneyRobert S DiPaola

❮ Previous
Next ❯

Citations

Jul 30, 2016·Archives of Pathology & Laboratory Medicine·Ian S Hagemann
Feb 2, 2017·International Journal of Molecular Sciences·Rick KampsAndrea Romano
Dec 23, 2017·Briefings in Bioinformatics·Jochen SingerNiko Beerenwinkel
May 22, 2017·Virchows Archiv : an International Journal of Pathology·Rance C Siniard, Shuko Harada

❮ Previous
Next ❯

Related Concepts

Related Feeds

Ataxia telangiectasia

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Ataxia telangiectasia (MDS)

Ataxia telangiectasia is a rare neurodegenerative diseases caused by defects in the ATM gene, which is involved in DNA damage recognition and repair pathways. Here is the latest research on this autosomal recessive disease.

Cancer Sequencing

Several sequencing approaches are employed to understand and examine tumor development and progression. These include whole genome as well as RNA sequencing. Here is the latest research on cancer sequencing.