Development of a compensation algorithm for accurate depth localization in diffuse optical tomography

Optics Letters
Haijing NiuHanli Liu

Abstract

Diffuse optical tomography endures poor depth localization, since its sensitivity decreases severely with increased depth. In this study, we demonstrate a depth compensation algorithm (DCA), which optimally counterbalances the decay nature of light propagation in tissue so as to accurately localize absorbers in deep tissue. The novelty of DCA is to directly modify the sensitivity matrix, rather than the penalty term of regularization. DCA is based on maximum singular values (MSVs) of layered measurement sensitivities; these MSVs are inversely utilized to create a balancing weight matrix for compensating the measurement sensitivity in increased depth. Both computer simulations and laboratory experiments were performed to validate DCA. These results demonstrate that one (or two) 3-cm-deep absorber(s) can be accurately located in both lateral plane and depth within the laboratorial position errors.

References

Aug 7, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Joseph P CulverA G Yodh
Nov 1, 2003·Optics Letters·Joseph P CulverDavid A Boas
Mar 19, 2005·Physics in Medicine and Biology·A P GibsonS R Arridge
Mar 6, 2008·Applied Optics·B W PogueK D Paulsen

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Citations

Jul 24, 2014·IEEE Transactions on Medical Imaging·Chen ChenJunzhou Huang
Sep 19, 2012·Journal of Neuroscience Methods·Ming RenShao-Hua Yang
May 9, 2012·Biomedical Optics Express·Venkaiah C KavuriHanli Liu
Oct 5, 2016·Biomedical Optics Express·Hoang-Dung Nguyen, Keum-Shik Hong
Jan 23, 2015·Journal of Biomedical Optics·Tuo ZhouIchiro Sakuma

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