Development of a Composite of Polypyrrole-Coated Carbon Nanotubes as a Sonosensitizer for Treatment of Melanoma Cancer Under Multi-Step Ultrasound Irradiation.

Ultrasound in Medicine & Biology
Niloufar BehzadpourN Sattarahmady

Abstract

Sonodynamic therapy (SDT) has established a novel route for treating solid cancers. Low-intensity ultrasound irradiation accompanied by a sonosensitizer has revealed remarkable advantages for cancer therapy such as targeted uptake, access to deeper tumors, insignificant side effects and invasiveness, compared with other therapeutic methods. In this study, we scrutinized synthesis and characterization of a polypyrrole-coated multi-walled carbon nanotubes composite (PPy@MWCNTs). PPy@MWCNTs can absorb ultrasound irradiation by both of its components, and it was introduced as a new sonosensitizer. The composite was characterized by field emission scanning electron microscopy (FESEM), and its ability to temperature elevation was explored. FESEM images revealed that PPy@MWCNTs comprised nanotubes of 36.3 ± 5.1 nm in diameter with up to several micrometer in length. Ultrasound irradiation at 1 MHz and 1.0 W cm-2 for 60 s in four steps led to an efficient SDT in vitro (16.3 ± 2.8°C temperature increment for 250 μg mL-1 of PPy@MWCNTs), in C540 (B16/F10) cell line and a melanoma tumor model in male balb/c mice. In vitro examinations revealed that PPy@MWCNTs represented a concentration-dependent cytotoxicity on multi-step ultrasound irrad...Continue Reading

References

Apr 21, 2005·Journal of the American Chemical Society·Nadine Wong Shi Kam, Hongjie Dai
Oct 4, 2006·Journal of the Royal Society, Interface·D D AtehP Vadgama
Sep 1, 2007·Analytica Chimica Acta·S GeethaD C Trivedi
Jun 1, 2010·Ultrasound in Medicine & Biology·Amir H Barati, Manijeh Mokhtari-Dizaji
Oct 5, 2010·Ultrasound in Medicine & Biology·Xiaobing WangYixiang Li
Oct 18, 2012·Ultrasonics Sonochemistry·Bei ChenWeimin Zhang
Apr 9, 2013·ACS Nano·Chaenyung ChaAli Khademhosseini
Aug 30, 2013·Chemical Communications : Chem Comm·Enguo JuXiaogang Qu
Feb 26, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn J RuddyAnn H Partridge
Mar 3, 2015·Ultrasound in Medicine & Biology·Andrew K W Wood, Chandra M Sehgal
Jun 5, 2014·The Journal of Physical Chemistry Letters·Kenichi OzawaIwao Matsuda
Oct 22, 2015·Advances in Experimental Medicine and Biology·Anthony P McHaleBridgeen Callan
Jan 12, 2016·Analytical Biochemistry·A RahiH Heli
Feb 16, 2016·Chemical Reviews·Maan HayyanInas M AlNashef
Mar 22, 2016·Scientific Reports·Dong Gil YouJae Hyung Park
Jun 3, 2016·CA: a Cancer Journal for Clinicians·Kimberly D MillerAhmedin Jemal
Jul 15, 2016·The New England Journal of Medicine·Rudolph M NavariCharles L Loprinzi
Sep 27, 2016·Trends in Plant Science·Ron Mittler
Sep 14, 2017·Recent Patents on Nanotechnology·Masoud Negahdary, Hossein Heli
Sep 22, 2017·Journal of Gynecology Obstetrics and Human Reproduction·P MauriceJ-M Jouannic
Jul 1, 2018·World Neurosurgery·Nobuhiko AraiMakoto Inaba
Jun 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cuiling DuJunbai Li
Jul 14, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hui HouYongdong Jin

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Citations

Oct 30, 2020·International Journal of Nanomedicine·Yugo A MartinsRenata F V Lopez
Oct 2, 2021·Bioconjugate Chemistry·Juan GuoHuiyu Liu

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