Development of a comprehensive dietary antioxidant index and application to lung cancer risk in a cohort of male smokers

American Journal of Epidemiology
Margaret E WrightDemetrius Albanes

Abstract

In many observational studies, a higher intake of individual antioxidants is inversely associated with lung cancer risk. Data from in vitro and animal experiments suggest that there are biochemical interactions among antioxidant nutrients; therefore, consideration of multiple antioxidants simultaneously may be important in terms of risk estimation. The authors constructed a dietary antioxidant index and evaluated its ability to predict lung cancer risk within the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study cohort. At baseline (1985-1988), 27,111 Finnish male smokers aged 50-69 years completed a dietary questionnaire that assessed usual frequency of consumption and portion sizes for the previous 12 months. A total of 1,787 incident cases of lung cancer were identified during a follow-up period of up to 14.4 years (1985-1999). Principal components analyses were individually applied to the carotenoid, flavonoid, and vitamin E nutrient groups, and summation of retained principal component scores, plus selenium and vitamin C, yielded the composite antioxidant index. In multivariate proportional hazards models, the relative risks for lung cancer according to increasing quintiles of the antioxidant index were 1.00 (referen...Continue Reading

Citations

Jul 25, 2013·Biotechnology Letters·Zehou LiuYuming Wei
Jun 11, 2008·Cancer Causes & Control : CCC·Michael GoodmanJack Mandel
Apr 8, 2010·Critical Reviews in Food Science and Nutrition·Zorabel CorderoHeiner Boeing
Aug 21, 2013·Critical Reviews in Food Science and Nutrition·Rosalie A M Dhonukshe-RuttenPieter Van't Veer
Apr 9, 2009·Japanese Journal of Clinical Oncology·Na-Ping TangJing Ma
Jan 15, 2005·Current Opinion in Lipidology·David C K Roberts
Sep 7, 2006·Postgraduate Medical Journal·A Shenkin
Sep 27, 2013·PloS One·Hae Dong Woo, Jeongseon Kim
Jan 16, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Emel Calişkan-CanSevgi Yardim-Akaydin
Oct 6, 2007·Chest·Anthony J AlbergUNKNOWN American College of Chest Physicians
Mar 31, 2012·Medicina clínica·Javier García-TiradoPablo Saz-Peiró
Jun 21, 2011·Free Radical Biology & Medicine·Michael GoodmanDean P Jones
Dec 15, 2010·Cancer Epidemiology·Ilir AgalliuThomas E Rohan
Feb 18, 2010·Journal of Food Composition and Analysis : an Official Publication of the United Nations University, International Network of Food Data Systems·Janice E StuffMichele R Forman
Sep 15, 2007·Annals of Epidemiology·Susan T MayneDemetrius Albanes
Jul 3, 2007·Journal of the American Dietetic Association·Suzen M MoellerPatricia M Guenther
Apr 3, 2016·Cancer Letters·Sahdeo PrasadAmit K Tyagi
Mar 13, 2017·American Journal of Nephrology·Titilayo O IloriAkinlolu O Ojo
Sep 29, 2005·The Annals of Pharmacotherapy·David Q Pham, Roda Plakogiannis
Jan 1, 2011·Cancers·Paola PalozzaMaria Cristina Mele
Apr 1, 2014·The Cochrane Database of Systematic Reviews·Marco VincetiCinzia Del Giovane
Jan 30, 2018·The Cochrane Database of Systematic Reviews·Marco VincetiCatherine M Crespi
Aug 12, 2006·Journal of Occupational and Environmental Medicine·David J LeeTerry Pitman
May 21, 2008·International Journal of Cancer. Journal International Du Cancer·Gretchen J CutlerKim Robien
Oct 16, 2012·Nutrition and Cancer·Krista Yorita ChristensenAnita Koushik
Jul 11, 2006·The American Journal of Clinical Nutrition·Bente L HalvorsenRune Blomhoff
Aug 12, 2008·The American Journal of Clinical Nutrition·Lisa GallicchioAnthony J Alberg
Aug 12, 2020·International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition·Mahdieh Abbasalizad FarhangiPourya Fathollahi
Aug 18, 2009·International Journal of Cancer. Journal International Du Cancer·Monica BertoiaMargaret E Wright
Oct 30, 2009·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Fabrizio VegliaViviana Cavalca
Jan 21, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·So Yeon J KongMichael Goodman

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