Development of a concise and diversity-oriented approach for the synthesis of plecomacrolides via the diene-ene RCM

Organic Letters
Kui LuZhen Yang

Abstract

[reaction: see text] A concise synthesis of the core structures of plecomacrolide with ring sizes varying from 16 to 19 atoms was achieved for the first time by the diene-ene ring-closing olefin metathesis reaction. This approach should allow access to the structurally diverse analogues of plecomacrolide.

References

Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·E J BowmanK Altendorf
Mar 1, 1987·The Journal of Antibiotics·M DeegA Kretschmer
Nov 1, 1985·The Journal of Antibiotics·J H WiltonJ C French
Nov 1, 1984·The Journal of Antibiotics·H KinashiK Sakaguchi
May 1, 1984·The Journal of Antibiotics·H SetoN Otake
Nov 1, 1982·The Journal of Antibiotics·H KinashiT Miyazawa
Jan 1, 1996·The Biochemical Journal·A J SaurinS R Pennington
Feb 15, 2001·Accounts of Chemical Research·T M Trnka, R H Grubbs
Mar 23, 2001·The Journal of Organic Chemistry·K ToshimaS Matsumura
Oct 18, 2001·Journal of the American Chemical Society·S HanessianY Gai
May 16, 1997·The Journal of Organic Chemistry·Kazunobu ToshimaShuichi Matsumura
Nov 1, 2001·Journal of the American Chemical Society·R M GarbaccioS J Danishefsky
Feb 22, 2002·The Journal of Organic Chemistry·James A Marshall, Nicholas D Adams
Jun 13, 2002·Journal of the American Chemical Society·Karl A ScheidtWilliam R Roush
Aug 15, 2002·Journal of the American Chemical Society·Kaustav BiswasSamuel J Danishefsky
Feb 12, 2005·Organic Letters·Yuuki HirayamaMichiko Iwamura

❮ Previous
Next ❯

Citations

Jul 30, 2008·Natural Product Reports·Christopher CordierCatherine O'Leary-Steele
Sep 22, 2007·Science·Emily P Balskus, Eric N Jacobsen
Sep 7, 2016·Organic Letters·Jun Huang, Zhang Wang
Sep 5, 2007·Chemistry : a European Journal·Alois FürstnerRichard Mynott
Nov 14, 2019·Chemical Communications : Chem Comm·Shyamsundar DasByung Chul Lee
Oct 14, 2020·European Journal of Medicinal Chemistry·Alicia BauduinPaul-Alain Jaffrès
Mar 6, 2021·The Journal of Organic Chemistry·Makoto SasakiKeisuke Arai
Mar 20, 2009·Organic Letters·Lin WangZhen Yang
Sep 20, 2007·Journal of Combinatorial Chemistry·Roland E DolleWei Zhang
Apr 29, 2021·The Journal of Organic Chemistry·Subramanian G GramaniMartin J Lear
Jul 24, 2021·The Journal of Organic Chemistry·Stephan ScheeffDirk Menche
May 6, 2010·The Journal of Organic Chemistry·Takehiko YoshimitsuTetsuaki Tanaka
Dec 15, 2018·Organic Letters·Stephan Scheeff, Dirk Menche
May 12, 2011·Journal of the American Chemical Society·Yikai WangDamian W Young
May 25, 2011·Journal of the American Chemical Society·Daniel Gallenkamp, Alois Fürstner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Organic Chemistry
Yuguo DuRobert J Linhardt
Angewandte Chemie
Alois FürstnerMario Waser
Journal of the American Chemical Society
Porino Va, William R Roush
© 2021 Meta ULC. All rights reserved