Development of a cost-effective production process for Halomonas levan

Bioprocess and Biosystems Engineering
Burak Adnan ErkorkmazEbru Toksoy Oner

Abstract

Levan polysaccharide is an industrially important natural polymer with unique properties and diverse high-value applications. However, current bottlenecks associated with its large-scale production need to be overcome by innovative approaches leading to economically viable processes. Besides many mesophilic levan producers, halophilic Halomonas smyrnensis cultures hold distinctive industrial potential and, for the first time with this study, the advantage of halophilicity is used and conditions for non-sterile levan production were optimized. Levan productivity of Halomonas cultures in medium containing industrial sucrose from sugar beet and food industry by-product syrup, a total of ten sea, lake and rock salt samples from four natural salterns, as well as three different industrial-grade boron compounds were compared and the most suitable low-cost substitutes for sucrose, salt and boron were specified. Then, the effects of pH control, non-sterile conditions and different bioreactor modes (batch and fed-batch) were investigated. The development of a cost-effective production process was achieved with the highest yield (18.06 g/L) reported so far on this microbial system, as well as the highest theoretical bioconversion efficie...Continue Reading

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Citations

Aug 11, 2020·Engineering in Life Sciences·Nadja RadchenkovaMargarita S Kambourova
Sep 30, 2020·World Journal of Microbiology & Biotechnology·Peteris ZikmanisPavels Semjonovs
Apr 25, 2020·Food Science & Nutrition·Naoto ShimizuEbru Toksoy Öner
Jan 7, 2021·Applied Microbiology and Biotechnology·Rui ChengJianfa Zhang
Feb 21, 2021·International Journal of Biological Macromolecules·Mayra Alejandra López-OrtegaAdriana Inés Rodríguez-Hernández
Apr 23, 2021·Essays in Biochemistry·Jian-Wen Ye, Guo-Qiang Chen
Aug 23, 2021·International Journal of Biological Macromolecules·Zahra EskandariEbru Toksoy Oner

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