Abstract
The aim of this study was to develop a drug-in-adhesive patch for transdermal delivery of daphnetin (DA), which is a coumarin derivative in Girald Daphne, and to investigate the role of Transcutol P (TP) in the release and percutaneous permeation processes of DA. Backing films, permeation enhancers and enhancer content in the transdermal patch were investigated through in vitro experiments using rat skin. Anti-inflammatory and analgesic effects of the optimized formulation were evaluated using the adjuvant arthritis model and the pain model induced by acetic acid, respectively. In addition, the enhancement effect of TP was investigated using differential scanning calorimetry (DSC), FTIR, and molecular dynamic simulation. The optimal formulation, composed of DURO-TAK® 87-2852, CoTranTM 9680, 1% DA, and 10% TP showed anti-inflammatory and analgesic effects. It was found that TP only promoted the release process of DA from its transdermal patch. Furthermore, the decrease of interaction between drug and pressure sensitive adhesive (PSA) as well as the improvement of PSA mobility due to TP addition were the main factors that enhanced the release of DA from patch. This study successfully used TP to develop a DA patch with good anti-i...Continue Reading
References
Oct 18, 1969·Nature·W R Lieb, W D Stein
Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K MoserR H Guy
May 16, 2003·Nature·Gary S Firestein
Nov 13, 2003·Journal of Ethnopharmacology·Jeane SilvaF J A Matos
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Apr 25, 2008·Current Protocols in Immunology·W van EdenM H Wauben
May 22, 2008·Expert Opinion on Drug Delivery·Diksha KaushikBozena Michniak-Kohn
Oct 7, 2008·Journal of Ethnopharmacology·Qin GaoHuiqin Xu
Dec 25, 2008·Molecular Pharmaceutics·Emmanuel J SimonsDaniel S Kohane
Mar 13, 2009·Drug Delivery·Ziyi WenZhonggui He
Nov 17, 2009·Pharmaceutical Research·Sarah A Ibrahim, S Kevin Li
Jun 16, 2010·Molecular Pharmaceutics·Rania M HathoutRichard H Guy
Oct 14, 2010·Drug Delivery·Ying HuJian-Qing Gao
Jun 15, 2011·International Journal of Pharmaceutics·Nan LiJerry Zhang
Jul 17, 2012·International Journal of Pharmaceutics·Honglei XiLiang Fang
Apr 10, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Honglei XiLiang Fang
Jan 23, 2014·Molecular Pharmaceutics·Francesco CilurzoPaola Minghetti
Apr 12, 2015·International Journal of Pharmaceutics·Eunjae JungDae-DuK Kim
Feb 21, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenting SongLiang Fang
Citations
May 23, 2020·International Journal of Nanomedicine·Huimin LiLi Zhang
Dec 31, 2019·International Journal of Pharmaceutics·Himanshu KathuriaLifeng Kang
Mar 23, 2021·Journal of Biochemical and Molecular Toxicology·Qiang PeiRui Liu
Jun 29, 2021·International Immunopharmacology·Yifan YangDan Wang
Sep 4, 2021·Drug Delivery and Translational Research·Lijuan ZengWenting Song
Jan 15, 2022·AAPS PharmSciTech·Xue HanQing Wang