Development of a daphnetin transdermal patch using chemical enhancer strategy: insights of the enhancement effect of Transcutol P and the assessment of pharmacodynamics

Drug Development and Industrial Pharmacy
Meiyue ShenLiang Fang

Abstract

The aim of this study was to develop a drug-in-adhesive patch for transdermal delivery of daphnetin (DA), which is a coumarin derivative in Girald Daphne, and to investigate the role of Transcutol P (TP) in the release and percutaneous permeation processes of DA. Backing films, permeation enhancers and enhancer content in the transdermal patch were investigated through in vitro experiments using rat skin. Anti-inflammatory and analgesic effects of the optimized formulation were evaluated using the adjuvant arthritis model and the pain model induced by acetic acid, respectively. In addition, the enhancement effect of TP was investigated using differential scanning calorimetry (DSC), FTIR, and molecular dynamic simulation. The optimal formulation, composed of DURO-TAK® 87-2852, CoTranTM 9680, 1% DA, and 10% TP showed anti-inflammatory and analgesic effects. It was found that TP only promoted the release process of DA from its transdermal patch. Furthermore, the decrease of interaction between drug and pressure sensitive adhesive (PSA) as well as the improvement of PSA mobility due to TP addition were the main factors that enhanced the release of DA from patch. This study successfully used TP to develop a DA patch with good anti-i...Continue Reading

References

Aug 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·K MoserR H Guy
May 16, 2003·Nature·Gary S Firestein
Nov 13, 2003·Journal of Ethnopharmacology·Jeane SilvaF J A Matos
Mar 17, 2004·Advanced Drug Delivery Reviews·Adrian C Williams, Brian W Barry
Apr 25, 2008·Current Protocols in Immunology·W van EdenM H Wauben
May 22, 2008·Expert Opinion on Drug Delivery·Diksha KaushikBozena Michniak-Kohn
Oct 7, 2008·Journal of Ethnopharmacology·Qin GaoHuiqin Xu
Dec 25, 2008·Molecular Pharmaceutics·Emmanuel J SimonsDaniel S Kohane
Jan 23, 2014·Molecular Pharmaceutics·Francesco CilurzoPaola Minghetti
Feb 21, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wenting SongLiang Fang

❮ Previous
Next ❯

Citations

Dec 31, 2019·International Journal of Pharmaceutics·Himanshu KathuriaLifeng Kang
Mar 23, 2021·Journal of Biochemical and Molecular Toxicology·Qiang PeiRui Liu
Sep 4, 2021·Drug Delivery and Translational Research·Lijuan ZengWenting Song

❮ Previous
Next ❯

Related Concepts

Related Feeds

CREs: Gene & Cell Therapy

Gene and cell therapy advances have shown promising outcomes for several diseases. The role of cis-regulatory elements (CREs) is crucial in the design of gene therapy vectors. Here is the latest research on CREs in gene and cell therapy.