Development of a device for the delivery of agents to bone during distraction osteogenesis

The Journal of Craniofacial Surgery
B H GraysonJ G McCarthy

Abstract

Various agents have been theoretically and experimentally implicated as mediators of distraction osteogenesis (DO). The purpose of this study was to develop a vehicle for the potential delivery of these factors to the region of the distraction site in an attempt to manipulate this biologic process. Three adult mongrel dogs (12 months old) had oblique osteotomies performed bilaterally through the gonial regions. In group I, the external distracter was affixed to the right hemimandible of two dogs (n = 2 hemimandibles) with cannulated pins (external diameter = 1.5 mm; lumen diameter = 1.0 mm; length = 60 mm), whereas the distracter on the left was affixed with standard, noncannulated pins of the same dimensions. In group II, cannulated pins were used to affix the external distracter to both hemimandibles (n = 2 hemimandibles) of a dog. The devices were activated after a 5-day latency period and were lengthened at a rate of 1 mm/day for 20 days. During the distraction period, 0.1 ml/d of sterile india ink was injected into the cannulated pins, after which the sterile stylet was replaced. The activation protocol was followed by 28 days of fixation (consolidation period). The hemimandibles from group I underwent removal of soft tiss...Continue Reading

References

Jan 1, 1992·Plastic and Reconstructive Surgery·J G McCarthyB H Grayson
May 1, 1996·Trends in Genetics : TIG·J Ross
Aug 26, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M SatoT Ochi
Oct 22, 1998·The Journal of Craniofacial Surgery·J G McCarthyJ S Crombie
Nov 12, 1998·Plastic and Reconstructive Surgery·N M RoweM T Longaker
May 26, 1999·Annals of Plastic Surgery·D S SteinbrechM T Longaker

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Citations

Nov 3, 2009·The Journal of Craniofacial Surgery·Ersoy KonaşHalil Ibrahim Canter
Aug 5, 2004·Clinical Orthopaedics and Related Research·James Aronson

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