Development of a Diagnostic Clinical Score for Hemodynamically Significant Patent Ductus Arteriosus

Frontiers in Pediatrics
Annemarie KindlerSigrun Ruth Hofmann

Abstract

There is no consensus about the hemodynamic significance and, therefore, the need to treat a persistent ductus arteriosus in preterm newborns. Since the diagnosis of a hemodynamically significant persistent ductus arteriosus (hsPDA) is made by a summary of non-uniform echo-criteria in combination with the clinical deterioration of the preterm neonate, standardized clinical and ultrasound scoring systems are needed. The objective of this study was the development of a clinical score for the detection and follow-up of hsPDA. In this observational cohort study of 154 preterm neonates (mean gestational age 28.1 weeks), clinical signs for the development of hsPDA were recorded in a standardized score and compared to echocardiography. Analyzing the significance of single score parameters compared to the diagnosis by echocardiography, we developed a short clinical score (calculated sensitivity 84% and specificity 80%). In conclusion, this clinical diagnostic PDA score is non-invasive and quickly to implement. The continuous assessment of defined clinical parameters allows for a more precise diagnosis of hemodynamic significance of PDA and, therefore, should help to detect preterm neonates needing PDA-treatment. The score, therefore, a...Continue Reading

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Citations

Nov 27, 2019·Journal of Perinatology : Official Journal of the California Perinatal Association·Zachary CoffmanJason Buckley
Jul 13, 2019·BMC Pediatrics·Tendai MabhandiDaynia Elizabeth Ballot
Jan 16, 2021·Italian Journal of Pediatrics·Gianluca TerrinMario De Curtis
Apr 29, 2020·American Journal of Perinatology·Dalibor KurepaJohn Amodio

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