Development of a diagnostic polymersome system for potential imaging delivery

Colloids and Surfaces. B, Biointerfaces
Wen-Chia HuangHsin-Cheng Chiu

Abstract

In order to enhance visualization of soft tissues, a dual-imaging diagnostic polymersome system featured with highly hydrated multilamellar wall structure capable of simultaneously embedding a hydrophobic near-infrared fluorophore, Cy5.5, and a paramagnetic probe, gadolinium (Gd(III)) cations was developed. The polymersomes were obtained from the self-assembly of lipid-containing copolymer, poly(acrylic acid-co-distearin acrylate), in aqueous solution. The Cy5.5 and Gd(III) species were loaded into polymersomes via hydrophobic association (loading efficiency of Cy5.5 ca 74%) and electrostatic complexation (Gd(III) 83%), respectively. The Cy5.5/Gd(III)-loaded polymersomes (CGLPs) have shown excellent payload confinement, reduced dilution effect on assembly dissociation and decreased protein/salt-induced colloidal aggregation. Owing to the highly hydrated structure of vesicular membrane, the superior contrast enhancement of CGLPs in magnetic resonance (MR) imaging was obtained as a result of prolonged rotational correlation time of Gd(III) cations and fast water exchange from Gd(III) to bulk solution. The CGLPs exhibit a 15-fold higher longitudinal relaxivity value (ca 60 mM(-1) s(-1)) than that (4 mM(-1) s(-1)) of the commercial...Continue Reading

References

Mar 15, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Sophie LaurentRobert N Muller
Jun 24, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Zhiliang Cheng, Andrew Tsourkas
Dec 23, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomoyuki MizunoHirokazu Okamoto
Nov 7, 2009·PloS One·Ketan B GhaghadaAnanth Annapragada
Nov 5, 2011·Journal of Drug Targeting·Wen-Chia HuangHsin-Cheng Chiu
Dec 12, 2012·Macromolecules·Christopher M AndolinaKenneth N Raymond
Apr 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wen-Hsuan ChiangHsin-Cheng Chiu

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Citations

Nov 14, 2015·Chemical Society Reviews·Cornelia G PalivanWolfgang Meier
Nov 23, 2015·Colloids and Surfaces. B, Biointerfaces·Marcela A MorettonDiego A Chiappetta
Sep 17, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Wen-Chia HuangHsin-Cheng Chiu
Jan 25, 2017·International Journal of Pharmaceutics·Marzieh MohammadiMona Alibolandi
Dec 30, 2020·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Michael MertzKathrin Castiglione

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