Development of a dual extrusion printing technique for an acid- and thermo-labile drug

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Wiebke KempinAnne Seidlitz

Abstract

Over the last years fused deposition modeling has been increasingly considered as a game-changing technique for the preparation of individualized pharmaceutical products. Until now investigations have mainly focused on dosage forms loaded with very stable drugs or model substances. Going beyond this early stage of research, developers will also have to deal with more challenging active substances. In this work different printing designs for tablets containing the acid- and thermo-labile drug pantoprazole sodium were tested. Initial dual extrusion printing of a cellulose acetate phthalate coat and a tablet core of polyethylene glycol 6000 with 10% (m/m) pantoprazole sodium resulted in thermal degradation of pantoprazole at cellulose acetate phthalate printing temperatures of 141 °C. Therefore, different tablet designs were developed. The sectioning of the design of the tablet coat in a gastro-resistant cellulose acetate phthalate bottom part and an upper nearly insoluble polycaprolactone part printed at only 58 °C was suitable to prevent visible signs of thermal degradation. Dissolution testing indicated also no drug loss during dual extrusion printing. However, printed enteric tablets with shell thicknesses of 0.4 to 0.5 mm wer...Continue Reading

Citations

Aug 30, 2019·Scientific Reports·Xiaowen XuJunliang Yang
Jul 4, 2020·Drug Development and Industrial Pharmacy·Ivana Cotabarren, Loreana Gallo
Dec 7, 2018·Current Pharmaceutical Design·Ilias El AitaJulian Quodbach
Apr 26, 2021·Advanced Drug Delivery Reviews·Shriya K PatelMohamed A Alhnan
May 14, 2021·International Journal of Pharmaceutics·I LafeberK J M Schimmel
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jolanta PyterafRenata Jachowicz
Nov 2, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sylvain CailleauxIan Soulairol
Jul 24, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Malte BogdahnWerner Weitschies
Aug 15, 2021·Advanced Drug Delivery Reviews·Georgios K EleftheriadisJukka Rantanen

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